摘要
目的:研究二陈汤加乌贝散对HP感染性消化性溃疡患者的临床疗效,以期为临床治疗提供依据。方法:选取我院确诊为HP感染性消化性溃疡患者200例,按照随机原则,将患者分成治疗组和对照组。其中对照组患者100例,给予单纯西医三联疗法治疗,治疗组患者100例给予二陈汤加乌贝散联合三联疗法,治疗周期为4周。于治疗前后观察两组患者的血清炎性因子、胃黏膜TGF-β1蛋白的表达、胃镜溃疡的疗效、HP抑制率、中医证候疗效及不良反应情况。结果:治疗4周后,治疗组患者的血清炎性相关因子水平均低于对照组(P<0.05),治疗组患者胃黏膜TGF-β1蛋白的表达低于对照组(P<0.05),治疗组患者的胃镜溃疡有效率88%优于对照组70%(P<0.05),治疗组的HP抑制率91%优于对照组72%(P<0.05),治疗组患者的中医证候积分均低于对照组(P<0.05)。结论:二陈汤加乌贝散联合三联疗法能有效降低血清炎症相关因子的水平,降低胃黏膜保护蛋白TGF-β1蛋白的表达,且能有效根除HP,促进溃疡的愈合,能有效改善患者的临床症状,临床疗效较高。
Objective:To investigate the clinical curative effect of Erchen decoction and Wubeisan in patients with peptic ulcer of HP infection,in order to provide the basis for clinical treatment.Methods:Diagnosed as peptic ulcer in patients with HP infection in 200 cases.It's randomly divided the patients into the treatment group and the control group,the control group of 100 patients,treated with western medicine triple therapy,treatment group 100 cases were treated with Erchen decoction plus Wubeisan combined with triple therapy,treatment cycle for 4 weeks.Before and after treatment,the serum inflammatory factors,the expression of TGF-beta 1 protein in gastric mucosa,the curative effect of gastroscope ulcer,the rate of negative HP,the curative effect of TCM syndrome and the adverse reactions were observed before and after treatment in two groups.Results:After 4 weeks of treatment,serum inflammatory factors levels of patients in the treatment group were lower than the control group(P<0.05).The treatment group the expression of protein TGF-beta 1 in gastric mucosa of patients was lower than that of control group(P<0.05).Gastroscopy ulcer patients with effective treatment group 88% than the control group 70%(P<0.05).The treatment group HP negative rate 91% than the control group 72%(P<0.05).TCM syndrome score of patients in the treatment group were lower than the control group(P<0.05).Conclusion:Erchen decoction and wubeisan combined with triple therapy can effectively reduce the level of serum inflammation related factors,decrease the expression of gastric mucosa TGF-protein beta 1 protein,and can effectively eradicate HP,promote ulcer healing,it can effectively improve the clinical symptoms of the patients,and has high clinical efficacy,fewer side effects.
出处
《陕西中医》
2017年第12期1679-1682,共4页
Shaanxi Journal of Traditional Chinese Medicine
关键词
消化性溃疡
中西医结合疗法
HP感染性
二陈汤
乌贝散
Peptic ulcer/integrated Chinese traditional and western medicine therapy
HP infection
Erchen decoction
Wubeisan
