摘要
目的探讨丹参川芎嗪注射液联合注射用尤瑞克林治疗急性脑梗死的临床疗效。方法选取2015年5月—2016年6月在安阳市人民医院治疗的急性脑梗死患者79例为研究对象,将所有患者采用分层随机法分为对照组(39例)和治疗组(40例))。对照组缓慢静脉滴注注射用尤瑞克林,0.15 PNA单位加入到生理盐水250 mL中,1次/d。治疗组在对照组的基础上静脉滴注丹参川芎嗪注射液,5 mL加入到生理盐水250 mL中,1次/d。两组患者均连续治疗7 d。观察两组的临床疗效,比较两组的NIHSS评分、Barthel评分、血液流变学指标情况。结果治疗后,对照组和治疗组的总有效率分别为71.8%、90.0%,两组比较差异有统计学意义(P<0.05)。治疗后,两组NIHSS评分显著降低,Barthel评分明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组全血高切黏度、全血低切黏度、红细胞比容、血小板聚集率和纤维蛋白原水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论丹参川芎嗪注射液联合注射用尤瑞克林治疗急性脑梗死具有较好的临床疗效,可促进神经功能恢复,提高日常生活能力,改善患者血液流变学指标,具有一定的临床推广应用价值。
Objective To investigate the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Urinary Kallidinogenase for injection in treatment of acute cerebral infarction. Methods Patients （79 cases） with acute cerebral infarction in Anyang People＇s Hospital from May 2015 to June 2016 were randomly divided into the control group （39 cases） and the treatment group （40 cases）. Patients in the control group were slowly iv administered with Urinary Kallidinogenase for injection, 0.15 PNA unit added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 5 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and NIHSS scores, Barthel scores, and blood rheology indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.8% and 90.0%, respectively, and there was difference between two groups （P 〈 0.05）. After treatment, the NIHSS scores in two groups were significantly decreased, but the Barthel scores in two groups were significantly increased, and the difference was statistically significant in the same group （P 〈 0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. After treatment, the level of high blood viscosity, low blood viscosity, hematocrit, platelet aggregation rate, and fibrinogen in two groups were significantly decreased, and the difference was statistically significant in the same group （P 〈 0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups （P 〈 0.05）. Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Urinary Kallidinogenase for injection has clinical curative effect in treatment of acute cerebral infarction, can promote the recovery of nerve function, raise the ability of daily life, and improve the blood rheology index, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2017年第11期2091-2094,共4页
Drugs & Clinic
关键词
丹参川芎嗪注射液
注射用尤瑞克林
急性脑梗死
NIHSS评分
Barthel评分
血液流变学
Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection
Urinary Kallidinogenase for injection
acute cerebral infarction
NIHSS score
Barthel score
blood rheology
