摘要
非酒精性脂肪性肝病(NAFLD)是一种发病机制复杂的慢性肝病,可由单纯脂肪肝发展为脂肪性肝炎,最终发展为肝纤维化或肝硬化,甚至肝癌,并增加了某些肝外疾病(如糖尿病、结直肠癌、慢性肾脏病、心血管事件及各种内分泌疾病)的发生率。NAFLD的治疗仍在不停探索中,但目前仍无特效药物。减轻体重是NAFLD的主要治疗,但难以维持且易反弹,因此药物治疗非常必要。文章结合近年来对NAFLD的治疗研究,对其治疗进展进行综述。
Nonalcoholic fatty liver disease （NAFLD） is a chronic liver disease with complicated pathophysiology and mechanism. It could manifest as simple steatosis, steatohepatitis, liver fibrosis or cirrhosis, even liver cancer. It also increases the incidence of some extraheptic diseases, such as diabetes, colorectal cancer, chronic kidney- disease, cardiovascular events and other endocrine disorders. There is no specific drug for NAFLD. Although weight loss is the basis of treatment for NAFLD, it is hard to maintain. The advancement in studies on the treatment of NAFLD was discussed in this review based on the studies on NAFLD treatment in recent years.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2017年第12期1069-1073,共5页
Chinese Journal of Practical Internal Medicine
基金
国家自然学基金(81460122)
江西省科技厅省自然科学基金(20171BAB215008)
江西省杰出青年人才资助计划(20171BCB23085)
江西省卫生及计划生育委员会科技计划项目(20171021)
