摘要
目的分析终末期糖尿病肾病患者院内感染的病原菌分布及耐药性。方法随机选取该院96例终末期糖尿病肾病患者,收集其尿液、血液及痰液等标本,对病原菌进行药敏试验鉴定。结果全组病原菌感染率为27.08%,共分离103株病原菌,其中15株真菌,42株革兰阴性菌及46株革兰阳性菌。真菌对氟胞嘧啶、两性霉素B及氟康唑的敏感率均为100.00%,对其他抗菌药物均能表现较高敏感率;革兰阳性菌对万古霉素及替考拉宁敏感性均为100.00%,对青霉素、磺胺甲噁唑等敏感性较弱;革兰阴性菌对哌拉西林及亚胺培南敏感性较高,对氨曲南及头孢类抗菌药敏感性较弱。结论由于终末期糖尿病肾病患者抵抗力低下与临床抗菌药物的滥用,患者机体内菌群失调,导致院内感染发生率高,因此对其院内感染的病原菌分布及耐药性进行分析有一定临床意义。
Objective To analyze the pathogens distribution and drug resistance of nosocomial infection in patients with end-stage diabetic nephropathy. Methods 96 cases of end-stage diabetic nephropathy were randomly selected in our hospital. The specimens of urine,blood and sputum were collected. The pathogens were identified by the drug susceptibility testing. Results The infection rate was 27. 08%. A total of 103 strains of pathogens were isolated,including 15 strains of fungi,42 strains of gram-negativebacteria and 46 strains of gram-positive bacteria. The drugs susceptibility rates of the fungi to flucytosine, amphotericin B and fluconazole were 100% ,and it also showed that the fungi had higher sensitivity to other common antibiotics ; the drug susceptibilityrates of gram-positive bacteria to vancomycin and teicoplanin were 100%, while its drug susceptibility ability to penicillin, strepto-mycin and others were weak;the drug susceptibility rates of gram-negative bacteria to piperacillin and imipenem were high, while itsdrug susceptibility ability to aztreonam and cephalosporin were weak. Conclusion The low resistance in the patients with end-stagediabetic nephropathy the abuse of clinical antiseptic drugs lead to the dysbacteriosis , resulting in a significant increase of the incidence of nosocomial infection,so the analysis of pathogens distribution and drug resistance of nosocomial infection has clinical significance.
出处
《国际检验医学杂志》
CAS
2017年第23期3270-3273,共4页
International Journal of Laboratory Medicine
关键词
终末期糖尿病肾病
院内感染
病原菌分布
耐药性
end-stage diabetic nephropathy
nosocomial infection
pathogen distribution
drug resistance
