摘要
目的观察丹参酮ⅡA磺酸钠注射液治疗狼疮性肾炎(LN)的疗效。方法将43例LN患者随机分为2组,对照组18例予LN常规治疗,即激素标准疗程加免疫抑制剂注射用环磷酰胺冲击治疗,治疗组25例在对照组治疗的基础上加丹参酮ⅡA磺酸钠注射。检测2组治疗前及治疗3、6个月时肾功能指标[包括24 h尿蛋白定量、血肌酐(Cr)、尿素氮(BUN)]及抗核抗体(ANA)和抗双链DNA(抗dsDNA)抗体阳性率变化,观察2组治疗前及治疗3、6个月时主要临床症状(面部红斑、手足红斑及皮肤溃疡)发生率变化,比较2组治疗过程中的不良反应,包括呼吸道感染、尿道感染、胃肠道症状、白细胞计数减少、脱发发生率。结果治疗组总有效率96.00%,对照组94.44%,2组总有效率比较差异无统计学意义(P>0.05)。2组治疗3个月时24 h尿蛋白定量、Cr、BUN较本组治疗前均无明显变化(P>0.05),治疗6个月时下降(P<0.05)。2组治疗3、6个月时ANA和抗dsDNA抗体阳性率均较本组治疗前降低(P<0.05),且治疗组治疗6个月时ANA和抗dsDNA抗体阳性率均低于对照组同期,比较差异有统计学意义(P<0.05)。2组治疗3、6个月时,面部红斑、手足红斑、皮肤溃疡发生率均较本组治疗前明显降低(P<0.05),且治疗组治疗3个月时手足红斑发生率,治疗6个月时面部红斑及手足红斑发生率均低于对照组同期(P<0.05)。治疗组呼吸道感染、尿道感染、胃肠道症状、白细胞计数减少及脱发发生率虽然较对照组有所降低,但比较差异均无统计学意义(P>0.05)。结论丹参酮ⅡA磺酸钠注射液在LN的治疗中有助于减少患者皮损症状发生率,降低患者体内抗dsDNA抗体及ANA阳性率。
Objective To observe the efficacy of Sulfotanshinone sodium injection on the treatment of lupus nephritis( LN). Methods 43 LN patients were randomly divided into two groups. The control group( n = 18) was given routine treatment of lupus nephritis,that is,the standard course of hormone therapy plus immunosuppressive agents injected with cyclophosphamide therapy. The treatment group( n = 25) was given Sulfotanshinone sodium injection on the basis of the control group. The renal function indexes including 24 hurine protein quantitation,serum creatinine( Cr),blood urea nitrogen( BUN),and the positive rate changes of antinuclear antibody( ANA) and anti-double stranded DNA( anti-dsDNA) antibody before and after treatment 3 months and 6 months were detecteed in two groups. The incidence changes of the main clinical symptoms including erythema of the face,erythema of the hands and foots and and skin ulcers before and after treatment 3 months and 6 months were observed in two groups.Adverse reactions in the two groups were compared,including the incidences of respiratory tract infection,urinary tract infection,gastrointestinal symptoms,the decrease of white blood cell count and hair loss. Results There was no statistical difference on the totoal effective rate between the treatment group( 96. 00%) and the control group( 94. 44%,P > 0. 05). There was no obvious changes on 24 hurine protein quantitation,Cr and BUN after treatment3 months in two groups( P > 0. 05). The 24 hurine protein quantitation,Cr and BUN after treatment 6 months were reduced in the two groups( P < 0. 05). The positive rates of ANA and anti-dsDNA antibody in both groups after treatment 3 months and 6 months were lower than those before treatment in both groups( P < 0. 05). The positive rates of ANA and anti-dsDNA antibody after treatment 6 months in treatment group were lower than those in the control group at the same period,wtih statistical differences( P < 0. 05). The incidences of the erythema of the face,erythema of the hands and foots and and skin ulcers after treatment 3 months and 6 months were obviously reduced in two groups( P < 0. 05). The incidence of the erythema of the face after treatment 3 months and the incidences of the erythema of the face,erythema of the hands and foots after treatment 6 months in the treatment group were lower than those in the control group at the same period( P < 0. 05). The incidences of respiratory tract infection,urinary tract infection,gastrointestinal symptoms,the decrease of white blood cell count and hair loss in the treatment group were lower than those in the control group wtih no statistical difference( P > 0. 05). Conclusion Sulfotanshinone sodium injection on the treatment of LN contributes to reduce the incidence of skin lesions and reduce the anti-dsDNA antibody,ANA antibody titers in vivo.
出处
《河北中医》
2017年第11期1632-1636,共5页
Hebei Journal of Traditional Chinese Medicine
关键词
狼疮肾炎
丹参酮ⅡA
中药疗法
Lupus nephritis
Sulfotanshinone
Traditional Chinese medicine therapy
