摘要
脑微出血（cerebral microbleeds，CMBs）是脑内微小血管病变所致微量血液渗漏、小血管周围含铁血黄素沉积的一种亚临床损害，是脑小血管病的重要影像学标志之一。近年来，随着新MRI序列的发展CMBs的检测率明显提高，脑微出血已经成为神经影像学领域的研究热点，尤其是在血管性认知功能障碍中的重要作用日渐受到了人们的重视。现就CMBs的流行病学现状、病理机制、危险因素、影像学表现、临床特点以及优化治疗方案等方面进行综述。以期为脑血管疾病以及血管性认知障碍的早预防、早诊断、早治疗提供理论支持。
Cerebral microbleeds （CMBs） ,as an important imaging marker of cerebral small vessel disease （ CSVD）, is a subclinical damage caused by small hemosiderin deposits indicative of prior cerebral microscopic hemorrhage. In recent years,CMBs have become an important research issue in the field of neu- roimaging with the development of newer magnetic resonance imaging （ MRI ） methods for the higher detec- tion rate of the CMBs. It must to be mentioned that CMBs plays a crucial role in the formatting process of vascular cognitive impairment （ VCI）, which caused researcher＇ s attention. This review focuses on the re- search progress in epidemiological status, pathological mechanisms, risk factors, imaging manifestations, clini- cal features and treatment therapies of CMBs, in order to provide theoretical references for the early detection, prevention and treatment of CSVD and VCI.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2017年第11期1046-1049,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目（81301016,81271309）
北京市青苗计划基金项目（QML20150303）
关键词
脑微出血
认知功能障碍
磁敏感加权成像
Cerebral microbleeds
Cognitive impairment
Susceptibility-weighted imaging
