摘要
抑郁症是一种常见的严重精神疾患,而柴胡疏肝散作为疏肝理气的经典方剂,其抗抑郁疗效已经大量临床研究及动物实验证实,但其抗抑郁有效成分及其作用机制尚不清楚。文章就近年来国内外对柴胡疏肝散抗抑郁的临床应用、药理作用及化学成分研究进展进行归纳,总结出柴胡疏肝散抗抑郁作用的药理研究目前集中在影响神经递质、神经可塑性、神经内分泌、细胞因子、氧化应激及能量代谢方面,其物质基础研究可能主要涉及了柴胡皂苷A、橙皮苷、甘草苷、芍药苷、芍药内酯苷及阿魏酸等,进一步确证了柴胡疏肝散作为经典抗抑郁古方所具备的多成分、多层次、多途径、多靶点等特点。
Depression is a common serious psychiatry disorder. Chaihu Shugan Powder（ CHSGS） is a classical prescription for soothing liver and regulating qi in traditional Chinese medicine and its anti-depression effecacy has been validated by some clinical trials and animal studies,but its active ingredients with potential antidepressant effects and their mechanism remain unclear.This review summarized the clinical application,pharmacological activities and active ingredients of CHSGS in treating depression,and concluded that pharmacological research of anti-depression effect of CHSGS was mainly focused on neurotransmitters,neuroplasticity,neuroendocrine,cytokines,oxidative stress and energy metabolism. The anti-depression effective components of CHSGS have been proved to be saikoside A,hesperidin,liquiritin,paeoniflorin,albiflorin,ferulic acid,etc. CHSGS as a classic antidepressant Chinese prescription is further confirmed with many advantages,such as multi-ingredients,multi-level,multi-channel,multi-targets.
出处
《辽宁中医杂志》
CAS
北大核心
2017年第11期2434-2438,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81574038
81503415)
广东省科技计划项目(2014A020221062)
深圳市科技研发资金项目(JCYJ20120618102107978)
深圳市卫计委项目(201302013)
关键词
柴胡疏肝散
抗抑郁
临床应用
药理作用
化学成分
Chaihu Shugan Powder
depression
clinical application
pharmacological activities
chemical ingredients
