摘要
目的评价聚桂醇泡沫硬化剂与无水乙醇硬化治疗颌面部静脉畸形的临床疗效.方法选取2014年5月至2016年8月在云南省第二人民医院口腔颌面外科住院治疗的63例颌面部静脉畸形的患者,分为A组(n=30)采用聚桂醇泡沫硬化剂治疗组.B组(n=33)采用无水乙醇注射硬化治疗组.对比分析A、B 2组的临床疗效,平均注射次数,平均治疗时间及并发症.结果 A、B 2组的总有效率均为100%,A组的治愈率为83.3%,B组的治愈率为90.9%,B组略高于A组,2组比较差异无统计学意义(P>0.05).A组平均注射次数为(4.5±1.3)次,B组为(2.0±0.7)次.A组的平均注射次数明显多于B组,差异有统计学意义(P<0.05).A组的平均治疗时间为(3.6±1.1)月,B组为(1.2±0.4)月.A组的平均治疗时间明显长于B组,差异有统计学意义(P<0.05).在术后并发症方面,A、B 2组肿胀发生率分别为86.7%及90.9%,差异无统计学意义(P>0.05).在疼痛,神经损伤,局部溃疡坏死及发热等方面.B组明显高于A组差异有统计学意义(P<0.05),2组患者均未发生肝、肾、肺的损害的严重并发症.结论聚桂醇及无水乙醇都是硬化治疗颌面部静脉畸形的首选药物,其中无水乙醇作用强,起效快,但不良反应多,聚桂醇的作用温和,需要的注射次数及治疗时间较无水乙醇长,术后并发症小,更适合在重要的解剖区域或重要的神经分布区使用.
Objective To evaluate the clinical efficacy of polycinnamic foam hardener and absolut ethanol inthe treatment of maxillofacial venous malformations. Methods From May 2014 to August 2016, 63 patients withmaxillofacial venous malformations were treated in the second people＇s Hospital of Yunnan province . They weredivided into groupA（n=30） and groupB（n=33） . Group A was treated with polycinnamic foam hardener andGroupB（n=33） was treated with absolute ethanol injection group. The clinical efficacy,the average times ofinjections, average treatment time and complications of patients in two groups were compared and analyzed. ResultsThe total effective rate of A and B two group was 100%, the cure rate of A group was 83.3%, the cure rate of B groupwas 90.9%,B group was slightly higher than that of groupA,the difference between the two groups was not statistically different（ P〉 0.05）. The average time of injections in group A was （4.5 ±1.3） times, and that in groupB was（2 ±0.7） times. The average time of injections in group A was significantly higher than that in groupB（ P〈0.05） . The average treatment time in group A was（3.6 ±1.1） months, and the B group was（1.2 ±0.4） months.The average duration of treatment in group A was significantly longer than that in groupB（ P〈 0.05） . In thepostoperative complications, the incidence of swelling in two groups of A andB were 86.7% and 90.9% respectively,and there was no significant difference （P 〉 0.05）. In pain, nerve damage, local ulceration, necrosis and fever,etc.Bgroup was significantly higher than the A group（ P〈 0.05）,and there were no serious complications of liver, kidneyand lung damage in the two groups. Conclusion Polycinnamic foam hardener and ethanol are hardening treatmentof maxillofacial venous malformation in which the drug of choice, ethanol effect is strong,fast,but more adverse re-actions, lauromacrogol effect is mild, injection time and treatment time need more ethanol, little postoperative compli-cations, more suitable for the anatomical region or an important use of nerve distribution.
出处
《昆明医科大学学报》
CAS
2017年第12期81-85,共5页
Journal of Kunming Medical University
基金
上海市重点学科建设基金资助项目(Y0203)
云南省医疗卫生单位内设研究机构基金资助项目(2017NS133)
关键词
静脉畸形
聚桂醇泡沫硬化剂
无水乙醇
Venous malformation
Polycinnamic foam hardener
Absolute ethanol
