摘要
目的探讨结肠癌组织中SATB2和P53蛋白的表达,并分析其表达与结肠癌临床病理特征的关系。方法采用免疫组化Max Vision法检测30例正常结肠组织和120例结肠癌组织中SATB2和P53蛋白的表达及其相关性。结果 SATB2在结肠癌组织中的表达低于正常结肠组织(P<0.05),并且与肿瘤大小、分化程度、浸润深度、淋巴结转移及TNM分期有关(P<0.05),与患者年龄、性别无关;P53蛋白在结肠癌组织中的表达明显高于正常结肠组织(P<0.01),并且与肿瘤分化程度、浸润深度及TNM分期有关(P<0.05),与患者年龄、性别、肿瘤大小及淋巴结转移无关;结肠癌中SATB2蛋白与P53蛋白表达呈负相关(P<0.01)。结论与正常结肠组织相比,结肠癌组织中SATB2蛋白表达降低,P53蛋白表达升高,二者表达呈负相关。SATB2和P53蛋白表达水平对评价结肠癌患者预后有重要意义。
Objective To investigate the expression of SATB2 and P53 protein in coloreetal cancer and to analyze their relationship with the clinieal pathologie eharaeterislies. Methods The expression of SATB2 and P53 protein in 30 normal eoloreetal tissues and 120 eoloreelal cancer tissues were deteeted by immunohistoehemieal method, then analyzed their eorrelation. Results The expression of SATB2 in eoloreetal cancer was lower than that in normal eoloreetal tissues（P 〈 0.05） ; and its expression correlated with the tumor size, differentiation, inva- sion, depth, lymph node metastasis and TNM stages （ P 〈 0.05 ） , Mille not with age and gender. The expression of P53 in eoloreetal eaneer was significantly higher than that in normal eohwecla[ tissues （P 〈 0.01 ） , and its expres- sion correlated with differentiation, invasion deplh and TNM slages （ P 〈 0.05 ） , while not with age, gender, tumor size and lymph node metastasis. The expression of SATII2 and P53 in eoloreetal eaneer have negative correlation （P 〈 0.01 ）. Conclusions Compared with in normal eohweetal tissues, the expression of SATB2 declined and the expression of P53 increased in eolol＇eetal eaneer, while they have negative correlation. The expression levels of SATB2 and P53 protein have important significance to evaluale the prognosis of coloreetal cancel.
出处
《实用医学杂志》
CAS
北大核心
2017年第23期3945-3948,共4页
The Journal of Practical Medicine
