摘要
目的探讨云贵高原汉族人群细胞色素P450(CYP)2C18、维生素K环氧化物还原酶复合体亚单位1(VKORC1)、CYP2C9的基因型分布情况及其基因多态性与华法林稳定剂量的相关性。方法以2011年1月至2014年1月在该院行瓣膜置换术后持续服用华法林抗凝治疗的云贵高原汉族患者176例为研究对象,采集静脉血检测各位点基因型,分析基因型及等位基因频率分布,以及基因多态性与华法林稳定剂量的相关性。结果各位点基因型及等位基因频率分布均符合Hardy-Winberg遗传平衡(P>0.05);CYP2C18(rs7896133)、VKORC1(rs9923231)、CYP2C9(rs1057910)、CYP2C9(rs4086116)基因位点的基因多态性与华法林稳定剂量相关(P<0.05)。结论云贵高原汉族患者CYP2C18(rs7896133)、VKORC1(rs9923231)、CYP2C9(rs1057910)、CYP2C9(rs4086116)基因多态性可能是华法林稳定剂量个体差异的影响因素。
Objective To investigate the CYP2C18,VKORC1 and CYP2C9 genotype distribution situation and the correlation between their polymorphism with warfarin stable dose. Methods A total of 176 Yungui plateau Han patients with continuously warfarin anticoagulation therapy after valve replacement in this hospital from January 201t to January 2014 served as the research subjects. The venous blood was collected for detecting genotypes at various loci. The genotype and allele frequency distribution were analyzed,and the correlation between the gene polymorPhism with warfarin stable dose was analyzed. Results The genotypes and allele frequencies at various loci conformed to the Hardy-Winberg genetic balance （P〉0.05）. The polymorphisms of CYP2C18 （rs7896133） ,VKORC1 （rs9923231）,CYP2C9（rs1057910） and CYP2C9（rs4086116） gene loci were correlated with warfarin stable dose （P〉0.05）. Conclusion The gene polymorphism of CYP2C18（rs7896133） ,VKORC1 （rs9923231） ,CYP2Cg（rs1057910） and CYP2C9（rs4086116） in Yungui plateau Han patients may be the influence factors which contribute to warfarin stable dose personalized difference.
出处
《重庆医学》
CAS
北大核心
2017年第35期4974-4976,共3页
Chongqing medicine
基金
云南省科技厅-昆明医科大学应用基础研究联合专项资金项目(201501UH00141)
