摘要
Sox5定位于12p12.1,共包含29个外显子,可转录出5个异构体,其中L-SOX5A相对研究较多,其功能众多,如调节胚胎发育,决定细胞分化,还参与多种肿瘤的发生,如淋巴瘤、乳腺癌、胶质瘤和前列腺癌等。
Sox5 gene is located on 12 p12. 1 containing 29 exons. The gene can transcript 5 variants,thus produce 5 isoforms. L-SOX5 A is an isoform with multiple functions,include regulate embryonic development,and determine cell differentiation. Sox5 also plays a role in pathogenesis of prostate cancer,breast cancer and lymphoma.
出处
《基础医学与临床》
CSCD
2017年第12期1765-1769,共5页
Basic and Clinical Medicine
