摘要
[目的]探究NGAL通路关键因子与溃疡性结肠炎复发的相关性研究及临床应用。[方法]随机收集我院收治的89例溃疡性结肠炎患者,根据其严重程度分为轻、中度UC组与重度UC组,分别检测患者体内的NGAL通路关键因子水平,并对比分析两组患者治疗缓解后的复发情况。[结果]治疗前重度UC组患者的血清NGAL水平明显高于轻、中度UC组患者,差异有统计学意义(P<0.05)。治疗后重度UC组患者的血清NGAL水平与轻、中度UC组患者相比未见明显差异(P>0.05)。治疗缓解患者重度UC组停药后3个月、停药后6个月的复发率明显高轻、中度UC组患者,差异有统计学意义(P<0.05)。[结论]NGAL水平在溃疡性结肠炎患者中明显升高,且疾病活动程度越高,其NGAL水平升高越明显,患者的复发率也随之升高,控制患者NGAL水平,有利于预防疾病复发,具有重要临床意义。
[Objective]To study the correlation between the key factor of NGAL pathway and the recurrence of ulcerative colitis and its clinical application.[Methods]89 patients with ulcerative colitis were randomly selected.According to the severity of ulcerative colitis,the patients were divided into mild and moderate UC group and severe UC group.The levels of NGAL pathways in the patients were detected,and the relapse rate of the two groups was analyzed retrospectively.[Results]Serum NGAL levels in patients with severe UC were significantly higher than those in patients with mild to moderate UC（P〈0.05）.The recurrence rate of severe UC group was significantly higher than that of moderate UC group at 3 months and 6 months after remission（P〈0.05）.[Conclusion]The level of NGAL in patients with ulcerative colitis was significantly increased.And the higher the degree of disease activity,the more obvious NGAL levels increased.At the same time the recurrence rate of patients was also increased,It may have important clinical significance to control the levels of NGAL in patients with UC for prevention of disease recurrence.
出处
《中国中西医结合消化杂志》
CAS
2017年第11期812-814,819,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
公益技术研究社会发展项目(No:2014C33208)
