摘要
目的探讨氨溴索联合硫酸沙丁胺醇气雾剂对哮喘发作期患者血清白细胞介素-4(IL-4)及嗜酸性阳离子蛋白(ECP)水平的影响。方法选取中山市人民医院呼吸科门诊及病房就诊的处于发作期的哮喘患者120例,按照其就诊先后顺序分为试验组和对照组各60例,对照组患者仅给予硫酸沙丁胺醇气雾剂,维持治疗4周;试验组患者给予氨溴索联合硫酸沙丁胺醇气雾剂,并维持治疗4周。于治疗前检测两组患者IL-4、白细胞介素13(IL-13)、γ-干扰素(Interferon-γ,IFN-γ)及ECP、嗜酸性粒细胞直接计数(EOS)、免疫球蛋白E(IgE)水平,并于治疗结束后复查以上各项指标,同时比较治疗结束后两组患者临床总有效率。结果治疗后,两组患者血清IL-4及IL-13水平及ECP、EOS及IgE水平与治疗前相比均降低,IFN-γ与治疗前相比升高,差异均有统计学意义(P<0.05)。与对照组相比,试验组患者IL-4、IL-13水平较低,IFN-γ水平较高;ECP、EOS及IgE水平较低;临床总有效率较高,差异均有统计学意义(P<0.05)。结论氨溴索联合硫酸沙丁胺醇气雾剂能够降低哮喘发作期患者血清IL-4及ECP水平,减轻炎症反应,起到较好的治疗效果,值得临床推广。
Objective To investigate the effect of combined ambroxol and ventolin treatment on serum IL-4 and ECP levels in patients with asthma. Methods A total of 120 asthmatic patients who were being treated for an asthma attack were selected from our hospital outpatient department to participate in this study. According to the clinic,the patients were divided into the experimental group and control group,with 60 cases in each group. The patients in the control group were treated with ventolin alone;the experimental group was treated with ambroxol combined with ventolin and maintained for four weeks. The following indicators were assessed before treatment： interleukin 4（IL-4）,interleukin 13（IL-13）,interferon-gamma（Interferon-γ,IFN-γ）,and eosinophil cationic protein（ECP）,eosinophil cell count（EOS） and immunoglobulin E（IgE）levels; at the end of treatment,the above indicators were analyzed, and the two groups were compared for the total clinical efficiency. The results were analyzed using SPSS 19 statistical software. Results After treatment,the levels of serum IL-4 and IL-13 and ECP,EOS and IgE were compared in the two groups and were found to be decreased after treatment;the levels of IFN-γ before treatment was increased compared with after treatment;compared with the control group,the IL-4 levels of patients in the experimental group were lower;the IL-13 levels were lower;IFN-γ levels were higher（P〈0.05）;ECP,EOS and IgE levels were lower（P〈0.05）;and clinical total effective rate was higher（P〈0.05）. Conclusion Combined treatment with ambroxol and ventolin can reduce the attacks of asthma patients,reduce the serum IL-4 and ECP levels,and provide a better therapeutic effect that is worthy of clinical practice.
出处
《中华保健医学杂志》
2017年第6期477-479,共3页
Chinese Journal of Health Care and Medicine
