摘要
对于慢性HBV感染低复制期,大多数学者认为该期稳定,不需要治疗,只需长期随访即可。近年,由于HBeAg阴性慢性感染者比例上升,国内外学者对其认识不一,并且在大量临床实践中,发现其并非指南所指出的特征。肝活检是判断肝脏病理进展的"金标准",但它是一种有创检查,只能反映一时病理状态。为长期地动态观察这些患者,故对此期的临床特征进行论述,较系统性地了解该期患者性别、年龄、乙肝家族史、谷丙转氨酶(ALT)、HBsAg、HBV DNA及肝脏病理特点,旨在发现其规律,进而帮助临床医师指导诊治,规范其管理。
The low replication stage of CHB is the period which most doctors think needn＇t to treat but only follow up visit. Recently, the rising of the ratio of HBeAg-negative patients, the inconsistent knowing in the stage and a lot of clinic practices, the its features don＇ t accord with the guideline. Liver biopsy is a gold criterion that whether evaluates hepatitis reaction or not, but it is an invasive examine and only reflects the situation of the liver pathology temporarily. In order to observe these patients long-term dynamically. Therefore, we are going to do a discuss, systematically know a- bout the traits of patients of the stage. Such as gender, age, ALT, HBsAg quantitative level, HBeAg state and pathology of liver, aiming to find a rule, to help clinic physician diagnosis and treatment, to standard its management.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第12期1424-1427,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
陕西重点研发计划(2017SF-269)
