摘要
目的分析17例Ph1阳性慢性粒细胞白血病患者附加染色体异常克隆演变特征。方法采用常规染色体G显带技术,回顾性分析17例慢性粒细胞白血病患者遗传学资料。结果 219例Ph1阳性CML患者,17例附加染色体异常发生率7.8%,其中慢性期10例(6.8%),加速期3例(7.7%),急变期4例(11.8%)。结论在CML诊断、治疗及进展过程中,传统的染色体分析技术仍然是检测ACAs的唯一方法,并提示可能的致病性、预后和疗效。
Objective To investigate the clonal evolution of additional chromosomal abnormalities （ACAs）in Phila-delphia-positive cells with chronic myeloid leukemia （CML）.Methods Chromosome banding analysis was performed on bone marrow cells after 24 h short-term culture,and using conventional G-banding technique.Results 219 patients were enrolled and ACAs occurred in 17 patients（7.8%）,6.8% in chronic phase,7.7% in accelerated phase,and 11.8%in blast crisis （BC）.Conclusion Performing classic cytogenetics,both at diagnosis and during the course of the dis-ease,is still the only way to detect the presence of and/or the development of ACAs,along with the possible pathoge-netic,prognostic,and therapeutic implications.
出处
《中国实验诊断学》
2017年第12期2043-2046,共4页
Chinese Journal of Laboratory Diagnosis
基金
哈尔滨市科学技术局青年后备人才项目(No.2013RFQYJ081)
大连市卫生和计划生育委员会科研项目(No.1611115)
关键词
慢性粒细胞白血病
附加染色体异常:核型分析
Chronic myelogenous leukemia
Additional chromosome abnormalities
Karyotypic analysis
