摘要
目的探讨学龄期儿童中重度支气管哮喘急性发作的临床特点及其呼出气一氧化氮(Fe NO)与肺功能的相关性。方法收集本院收治的120例学龄期中重度支气管哮喘急性发作期患儿的临床资料(观察组),另选取同期来本院体检的100例正常健康学龄期儿童作为对照组,入院后均完成支气管激发试验、Fe NO检测、肺功能检查,比较两组上述指标差异,分析哮喘急性发作期Fe NO与肺功能的相关性。结果 (1)观察组中,男性占63.33%,有家族史占20.00%,有过敏性鼻炎占61.67%,被动吸烟占42.50%,中度哮喘占75.83%,哮喘初发占60.00%。过敏原中,螨为80.00%,室尘为70.00%。患儿总免疫球蛋白E(Ig E)水平高,发病季节以秋冬季节为主,合并肺炎为52.50%。(2)观察组Fe NO水平高于对照组(P<0.05),中度支气管哮喘患儿Fe NO水平低于重度患儿(P<0.05);(3)Fe NO与1秒用力呼吸容积占预计值百分比(FEV1%)呈负相关(P<0.05),与用力肺活量(FVC)和最大呼气流量(PEF)占预计值百分比(PEF%)均无明显相关性(P>0.05)。结论学龄期中重度支气管哮喘秋冬季节多发,男性多见,多伴过敏性鼻炎及肺炎,患儿血清总Ig E水平高;且患儿的Fe NO表达水平较高,与FEV1呈负相关。
Objective To explore the characteristics of moderate-severe acute attacks of bronchial asthma in children at school age and the correlation between the fractional exhaled nitric oxide（Fe NO） and their lung function. Methods The clinical data of 120 children patients at school age with moderate-severe acute attacks of bronchial asthma to receive treatment in our hospital were collected（an observation group）. Another 100 healthy children at school age who had received physical examination in our hospital in the same period were selected to constitute a control group. After admission, the two groups received bronchial stimulation test, Fe NO detection and lung function examination to compare the above-mentioned indexes and analyze the correlation between Fe NO and lung function in acute attacks of bronchial asthma. Results（1）In the observation group, male accounted for 63.33%; those with family history accounted for 20.00%, and allergic rhinitis 61.67%, passive smoking 42.50%, moderate asthma 75.83% and primary attack of asthma 60.00%. In terms of allergens, mite accounted for 80.00% and house dust 70.00%. The levels of total immunoglobulin E（Ig E）in children patients were high. The onset seasons mainly were autumn and winter, and the incidence of associated pneumonia was52.50%.（2）The levels of Fe NO in the observation group were higher than those in the control group（P 〈 0.05）, the levels of Fe NO in patients with moderate bronchial asthma were lower than those in severe children patients（P 〈 0.05）;（3）Fe No was negatively correlated with the percentage of forced expiratory volume in one second（FEV1%）（P 〈 0.05） and was not significantly correlated with the percentage of the forced vital capacity（FVC） and the maximum expiratory flow（PEF）（PEF%）（P 〉0.05）. Conclusion The attacks of bronchial asthma in children at school age are common in autumn and winter and males and are often complicated with allergic rhinitis and pneumonia. The serum total Ig E levels in children patients are high, and the Fe NO expression levels in children patients are high and are negatively correlated with EFV1.
出处
《西南国防医药》
CAS
2017年第12期1295-1298,共4页
Medical Journal of National Defending Forces in Southwest China
