摘要
目的探讨1.5 T磁共振不同NEX脑部肿瘤酰胺质子转移(amide proton transfer,APT)成像对ATP成像图像采集及后处理的影响。材料与方法采用GE Signa HDe 1.5 T MRI仪进行对比分析组和随机分组分析组病例的不同NEX的化学交换饱和转移(chemical exchange saturation transfer,CEST)成像和常规MRI检查的数据采集。CEST成像分别采集opmt=1,磁化传递频率为-224 Hz和224 Hz,及opmt=0 3组图像,并通过该3组图像进行后处理得出APT图。所得数据采用MATLAB平台上自主编译的后处理软件进行CEST-APT成像,分别对原始图信号、APT信号进行评价分析。数据分析采用SPSS 16.0进行独立样本t检验和方差分析等统计学分析。结果对比分析组,NEX=2和8,原始图图像质量得分分别为(4.55±0.83)分、(4.60±0.68)分,差异无统计学意义(P>0.05);APT图的图像质量得分分别为(2.7±1.03)分、(3.35±0.81)分,差异有统计学意义(P<0.05)。原始图检出率均为100%,APT图的敏感度分别为70%和90%。随机分组分析组,NEX=2和8,原始图图像质量得分分别为(4.54±0.78)分、(4.69±0.63)分,差异无统计学意义(P>0.05);APT图的图像质量得分分别为(2.89±0.96)分、(3.60±0.69)分,差异有统计学意义(P<0.05)。原始图检出率均为100%,APT图检出率分别为77.1%和94.3%。无论是哪一组的结果 ,APT图整体比原始图评分降一档。图像质量上APT图略差,但均能显示并区分病灶。结论优化参数后的APT成像,可以明确区分脑部肿瘤的病灶分布,从分子影像学层面呈现脑肿瘤的代谢物等生物学信息,早期诊断和综合评估肿瘤的范围及其与周围解剖结构的关系,对肿瘤的预后及治疗具有重要意义。如果受检者无法耐受,可以采用NEX为2次的参数采集,也可以提供相对满意的APT成像效果。
Objective： To analyze the effects of different number of excitation （NEX） amide proton transfer imaging in brain tumors on 1.5 T MRI scanner. Materials and Methods： The data acquisitions were carried out in clinical cases using GE Signa HDe 1.5 T MRI. The data were collected and analyzed on the analysis of the different NEX, such as the original signal, APT signal. Results： In the comparative analysis group, NEX=2 and 8, the original image quality scores were 4.55±0.83, 4.60±0.68, respectively, and there was no statistical difference; The image quality scores of the APT image were 2.7±1.03, 3.35±0.81 respectively, a statistically significant difference. The sensitivity of original image is 100%, and the sensitivity of APT image is 70% and 90%, respectively. In the random packet analysis group, NEX=2 and 8, the original image quality scores were 4.54±0.78, 4.69±0.63, respectively, and therewas no statistical difference; The image quality score APT image were 2.89±0.96,3.60±0.69, a statistically signifcant difference. The sensitivity of original image is 100%, and the sensitivity of APT image is 77.1% and 94.3%, respectively. No matter what a group of results, all APT images are down a fle than the original images. The APT images signal to noise ratio （SNR） is relatively low, but can display and distinguish lesions. Conclusions： APT imaging after optimizing parameters, the distribution of lesions can clearly distinguish brain tumors, brain tumors and other biological metabolites presenting information from the level of molecular imaging studies, the scope of early diagnosis and evaluation of tumor and its relationship with the surrounding anatomical structure, has important signifcance to tumor prognosis and treatment. If the subject is unable to tolerate, the APT image of NEX=2 can also provide relatively satisfactory APT imaging results.
出处
《磁共振成像》
CAS
CSCD
2017年第12期923-928,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
厦门市科技局科技惠民计划项目(编号:3502Z20144052)~~
关键词
磁共振成像
化学交换饱和转移
酰胺质子转移
脑肿瘤
Magnetic resonance imaging
Chemical exchange saturation transfer
Amide proton transfer
Brain neoplasms
