摘要
目的:研究经皮冠状动脉介入(PCI)术后QRS波与心肌缺血再灌注损伤、凋亡分子含量的相关性。方法:选择在南充市中心医院接受治疗的非ST段抬高型心肌梗死患者并对病史资料进行回顾性分析,分为接受急诊PCI手术治疗的PCI组以及接受择期PCI或拒绝急诊PCI治疗的对照组。治疗后1周后测定fQRS以及缺血再灌注损伤指标、凋亡分子含量。结果:PCI组患者fQRS的发生率显著低于对照组;PCI组患者血清中MDA、cTnI、H-FABP、sTWEAK、sFas、sTRAIL、Caspase-3的含量及外周血中Nrf-2、HO-1的表达量显著低于对照组;PCI组中fQRS波(+)患者血清中MDA、cTnI、HFABP、sTWEAK、sFas、sTRAIL、Caspase-3的含量及外周血中Nrf-2、HO-1的表达量显著高于fQRS波(-)患者。结论 :PCI术后fQRS波的发生与心肌缺血再灌注损伤以及细胞凋亡密切相关。
Objective:To study the correlation of QRS wave after percutaneous coronary intervention(PCI)with myocardial ischemia reperfusion injury and apoptosis molecule contents.Methods:Patients with non-ST-segment elevation myocardial infarction who were treated in Nanchong Central Hospital between June 2014 and August 2016 were selected and divided into the PCI group who received emergency PCI surgery and the control group who accepted selective PCI or refused emergency PCI after the medical data were retrospectively analyzed.The fQRS as well as the contents of ischemia reperfusion injury indexes and apoptosis molecules was determined after 1 week of treatment.Results:The incidence of fQRS in PCI group was significantly lower than that in control group;serum MDA,cTnI,H-FABP,sTWEAK,sFas,sTRAIL and Caspase-3 contents as well as peripheral blood Nrf-2 and HO-1 expression of PCI group were greatly lower than those of control group;serum MDA,cTnI,H-FABP,sTWEAK,sFas,sTRAIL and Caspase-3 contents as well as peripheral blood Nrf-2 and HO-1 expression of PCI group of patients with fQRS wave(+)were greatly higher than those of patients with fQRS wave(-).Conclusion:The occurrence of fQRS after PCI is closely related to myocardial ischemia reperfusion injury and apoptosis.
出处
《海南医学院学报》
CAS
2017年第21期2925-2928,共4页
Journal of Hainan Medical University
基金
2016年四川省卫计委课题(16PJ199)~~
关键词
经皮冠状动脉介入术
碎裂QRS波
缺血再灌注损伤
凋亡
percutaneous coronary intervention
fragmented QRS wave
ischemia reperfusion injury
apoptosis
