摘要
目的观察中药动员方辅助化疗+重组人粒细胞集落刺激因子(rh G-CSF)在自体造血干细胞移植(auto-HSCT)中动员外周血干细胞的疗效。方法 10例接受auto-HSCT治疗的血液肿瘤患者在化疗+rh GCSF动员外周血干细胞的基础上,同时服用中药动员方,每日1剂,全程服用中药动员方直至采集结束。对患者动员及采集结果进行观察,记录造血重建时间,并观察不良反应。结果 10例患者中有7例采集一次成功,3例采集两次成功;所有患者第一次采集单个核细胞数平均为(6.92±3.32)×108/kg,第一次采集CD34+细胞数平均为(3.66±2.50)×106/kg;所有患者行auto-HSCT后粒系植入中位时间为10天,血小板植入中位时间为12.50天;动员与采集过程中均无严重不良反应及感染发生。结论中药动员方辅助化疗+rh G-CSF在auto-HSCT中可增强动员外周血干细胞的效果,提高一次采集成功率,短时间内实现造血重建,且安全性较好。
Objective To observe the curative effect of Zhongyao Dongyuan Formula （~TY） in assisting chemotherapy plus recombinant human granulocyte colony stimulating factor （rhG-CSF） in mobilization of peripheral blood stem cells in autologous hematopoietic stem cell transplantation （auto-HSCT）. Methods Ten patients with hematological tumor having received auto-HSCT were given Zhongyao Dongyuan Formula, one dose daily, in addition to chemotherapy plus rhG-CSF for peripheral blood stem cells mobilization. Zhongyao Dongyuan Formula was taken during the whole course until the stem cell collection was complete. Results of the patient＇s mobilization and collection were observed. Time for hematopoietic reconstitution was recorded, and adverse reactions were observed. Results In 10 cases, stem cells of 7 cases were collected successfully at first collection, and those of another 3 cases were col- lected successfully at the second collection. The number of mononuclear cells collected at the first collection from each of patients was （6. 92 ＋3.32） x 10S/kg, and the number of CD34 ~ cells collected at the first collection was （3.66 ＋ 2.50） x 106/kg. The median time of granulocyte implantation was 10 days and that of platelet implantation was 12.50 days in all patients after auto-HSCT. There was no serious adverse reactions and infection during mobilization and collection process. Conclusion In auto-HSCT, Zhongyao Dongyuan Formula assisting chemotherapy plus rhG-CSF could reinforce the effect of peripheral blood stem cells mobilization, increase success rate of first collection, and achieve hematopoietic reconstruction in a short period of time, with good safety.
出处
《中医杂志》
CSCD
北大核心
2017年第24期2111-2114,共4页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81473511)
关键词
中药动员方
造血干细胞移植
血液病
血液肿瘤
Zhongyao Dongyuan Formula
hematopoietic stem cell transplantation
hematologic diseases
hemato-logic neoplasms
