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黄芪多糖对结肠炎小鼠结肠黏膜JAK/STAT信号的调控作用 被引量：30

Regulation of Astragalus polysaccharide treated colitis mice by JAK/STAT signaling pathway
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摘要 Janus活化激酶（Janus activated kinase,JAK）/信号转导与转录激活子（signal transducer and activator of transcriptions,STAT）途径介导了炎症性肠病的发生和发展[1]。黄芪多糖（Astragalus polysaccharides,APS）是黄芪的主要活性成分之一,可有效治疗实验性结肠炎[2],
作者 赵海梅 鹿秀云 岳海洋 刘億 刘雪珂 黄小英 刘端勇
机构地区 江西中医药大学基础医学院 江西中医药大学科技学院 江西中医药大学研究生院 江西中医药大学现代中药制剂教育部重点实验室
出处 《中国药理学通报》 CAS CSCD 北大核心 2018年第1期145-146,共2页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 81460679 81260595) 江西省自然科学基金资助项目(No 20122BAB215046) 江西省卫生厅中医药科研计划项目(No 2012A017)
关键词 黄芪多糖 结肠炎 疗效 JAK/STAT信号 SOCS 抑制 Astragalus polysaccharide colitis therapeutic effect JAK/STAT signaling pathway SOCS inhibition
分类号 R-332 [医药卫生] R284.1 [医药卫生—中药学]
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  • 1Joshua Ka-Shun Ko,Flora Ying-Lee Lam,Andrew Pok-Lap Cheung.Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis[J].World Journal of Gastroenterology,2005,11(37):5787-5794. 被引量：17
  • 2LANG S A, MOSER C, GAUMANN A, et al. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth faetor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth [ J ]. Clin Cancer Res, 2007, 13 (21) : 6459-6468.
  • 3OWAKI T, ASAKAWA M, MORISHIMA N, et al. STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Thl differentiation and suppression of proinflammatory cytokine production[ J ].J Immunol, 2008, 180 (5): 2903-2911.
  • 4VARIN A, LARBI A, DEDOUSSIS G V, et al. In vitro and in vivo effects of zinc on cytokine signalling in human T cells[J]. Exp Gerontol, 2008, 43 (5) : 472- 482.
  • 5FRITZENWANGER M, MEUSEL K, FOERSTER M, et al. Cardiotrophin-1 induces interleukin-6 synthesis in human monocytes [ J ] . Cytokine, 2007, 38 (3) : 137-144.
  • 6BEUREL E, JOPE R S. Differential regulation of STAT family members by glycogen synlhase kinase-3 [J]. J Biol Chem, 2008, 283 (32): 21934-21944.
  • 7SELVARAJ N G, OMI E, GIBORI G, et al. Janus kinase 2 ( JAK2 ) regulates prolactin-mediated chloride transport in mouse mammary epithelial cells through tyrosine phosphorylation of Na^+ -K^+ -2Cl- cotransporter [J]. Mol Endocrinol, 2000, 14 (12): 2054-2065.
  • 8HUANGJ S, CHUANGLY, GUHJY, etal. Effect of nitric oxide-cGMP-dependent protein kinasc activation on advanced glycation end-product-induced proliferation in renal fibroblasts [ J ]. J Am Soc Nephrol, 2005, 16 (8) : 2318-2329.
  • 9CHUANG L Y, GUH J Y, WANG K A, et al. Role of nitric oxide in high glucose-induced mitogenic response in renal fibroblasts[J]. Mol Endocrinol, 2006, 20 (10): 2548-2558.
  • 10ARAKAWA T, MASAKI T, HIRAI T, et al. Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomeruloncphritis[ J]. Nephrol Dial Transplant, 2008, 23 ( 11 ) : 3418-3426.

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中国药理学通报
2018年 第1期

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