摘要
背景:研究表明钛合金材料具有良好的生物相容性,便于加工合成为合适孔径的多孔结构,将其用于踝关节损伤中效果理想,但其生物力学性能尚不明确。目的:探讨多孔钛合金支撑棒在踝关节损伤中的应用效果及生物力学性能。方法:取健康Beagle犬30只,利用止血钳挑起并暴力拉断外侧副韧带,建立踝关节损伤模型。实验分为2组:对照组(n=15)和实验组(n=15)。利用CAD设计多孔钛合金棒三维模型,并将其输入到EBM S12系统中,将Ti6A14V粉末放入机器中并进行逐层熔融,最终制备成直径为4 mm、长度为12 mm的多孔圆柱状棒体。对照组采用常规方法修复,多孔钛合金支撑棒组将多孔钛合金支撑棒植入损伤处,比较2组犬踝关节肿胀程度、修复优良率、电生理学指标及生物力学性能。结果与结论:①2组修复前患侧踝关节周径无明显差异(P>0.05);多孔钛合金支撑棒组修复后1、2及3周,患侧踝关节周径均显著低于对照组(P<0.05);②多孔钛合金支撑棒组修复后3个月的优良率显著高于对照组(P<0.05);③2组Beagle犬修复前患侧外侧副韧带体感诱发电位和肌电图潜伏期、波幅比较无明显差异(P>0.05);多孔钛合金支撑棒组修复后3个月,患侧外侧副韧带体感诱发电位和肌电图的潜伏期显著短于对照组(P<0.05);而体感诱发电位和肌电图的波幅显著高于对照组(P<0.05);④与对照组相比,多孔钛合金支撑棒组的最大桡度、弹性桡度、破坏桡度无明显差异(P>0.05);而最大载荷、弹性载荷、破坏载荷及刚性系数显著提高(P<0.05);⑤结果提示,将多孔钛合金支撑棒应用于踝关节损伤的治疗,具有较好的修复效果,且有助于改善踝关节生物力学性能。
AbstractBACKGROUND： Studies have shown that titanium alloy with good biocompatibility can be easily processed andsynthesized to produce a porous structure with suitable pore diameter, which shows desired outcomes in the treatmentof ankle injury. Its mechanical performance, however, is yet unclear.OBJECTIVE： To investigate the effect and biomechanical properties of porous titanium alloy support rod in ankle jointinjuries.METHODS： The lateral ligaments of the ankle were lifted and ripped violently using a hemostatic forceps to make ankleinjury models in 30 healthy Beagle dogs. Animal models were randomized into two groups： control and experimentalgroups （n=15 per group）. A three-dimensional model of porous titanium alloy rod was established by using CAD software,and it was input into the EBM S12 system. Ti6A14V powder was added into the machine and melted layer by layer, andthen made into porous cylinder rods of 4 mm in diameter and 12 mm in length. The control group used conventionalrepair, and the experimental group underwent repair with porous titanium alloy support rod implantation. Degree of ankleswelling, excellent/good repair rate, and electrophysiological and biomechanical properties were compared between twogroups.RESULTS AND CONCLUSION： Ipsilateral ankle circumference showed no difference between the two groups beforetreatment （P 〉 0.05）, but after repair with porous titanium alloy support rod implantation, the experimental groups hadsignificantly lower ipsilateral ankle circumference than the control group （P 〈 0.05）. The excellent/good rate was alsosignificantly higher in the experimental group than the control group at 3 months after repair （P 〈 0.05）. For thesomatosensory evoked potential and electromyogram of the affected lateral ligament of the ankle, significantly lowerlatency and significantly higher amplitude was found in the experimental group than the control group at 3 months afterrepair, though there was no significant difference between the two groups before repair （P 〉 0.05）. Maximumperturbation, elastic disturbance and damage immunity had no significant difference between the two group （P 〉 0.05）,while the experimental group had significantly increased maximum load, elastic load, failure load and stiffness coefficientcompared with the control group （P 〈 0.05）. Overall, the porous titanium alloy support rod can achieve good outcomes inthe repair of ankle injury, and help to improve the biomechanical properties of the ankle.
出处
《中国组织工程研究》
CAS
北大核心
2017年第34期5413-5417,共5页
Chinese Journal of Tissue Engineering Research
基金
河北省卫生厅科研基金项目(20170108)~~
