摘要
目的探讨IL-18基因遗传多态与口腔癌发病的关系。方法检测IL-18基因rs1946519、rs187238和rs549908位点基因型在364例口腔癌患者(A组)和778例健康人群(B组)的分布,比较不同基因型与口腔癌发病的相关性。结果 A组rs549908位点AC和AC+CC基因型分布均低于B组(20.9%vs.28.0%和21.4%vs.31.6%)(P<0.05)。A组GGC单倍型分布低于B组(3.3%vs.6.3%)(P<0.05)。A组rs549908位点AA和AC+CC基因型患者血清IL-18水平高于B组[(473.61±110.76)pg/ml vs.(110.93±50.39)pg/ml和(489.00±108.65)pg/ml vs.(110.74±49.17)pg/ml](P<0.01)。结论 IL-18基因遗传多态与口腔癌的发病风险存在关联。
Objective To investigate the relationship between IL-18 gene polymorphisms and susceptibility of oral cancer.Methods The genotype distribution of IL-18 at rs1946519,rs187238 and rs549908 sites was detected in 364 patients with oral cancer（group A）and 778 healthy people（group B）.The correlation between different genotypes and susceptibility of oral cancer was compared.Results The distribution of AC and AC＋ CC genotypes at rs549908 site in group A was significantly lower than that in group B（20.9% vs.28.0% and 21.4% vs.31.6%）（P〈0.05）.The distribution of GGC haplotype in group A was also lower than that in group B（3.3% vs.6.3%）（P〈0.05）.Compared with group B,serum levels of IL-18 of AA and AC＋ CC genotypes at rs549908 site were obviously increased in group A[（473.61 ± 110.76）pg/ml vs.（110.93 ± 50.39）pg/ml and（489.00 ± 108.65） pg/ml vs.（110.74 ± 49.17）pg/ml]（P〈0.01）.Conclusion IL-18 gene polymorphisms may have a close relation to the susceptibility of oral cancer.
作者
韩旻轩
王林
HAN Minxuan;WANG Lin(Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, CHINA)
出处
《江苏医药》
CAS
2017年第23期1704-1706,共3页
Jiangsu Medical Journal
