摘要
目的探讨孟鲁司特对哮喘患的儿血清白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平地影响。方法选取100例患有支气管哮喘的患儿,随机分为观察组、对照组,每组患者均为50例。其中对照组的患儿给予布地奈德气雾剂吸入,对于观察组的患儿在此基础上给予孟鲁司特钠片口服。结果对于治疗后,观察组的患儿血清IL-4、TNF-α水平明显低于对照组,IFN-γ水平明显高于对照组,差异均有统计学意义(P<0.05)。观察组总有效率及症状改善情况均显著优于对照组(P<0.05)。结论孟鲁司特钠治疗小儿哮喘疗效确切,值得应用。
Objective To investigate the effect of montelukast on s e rum levels of interleukin -4 （IL-4） t u mor necrosis factor alpha （TNF-α） and interferon γ （IFN-γ） levels in children with asthma. Methods 100 children with bronchial asthma were randomly divided into observation group and control group, with 50 cases in each group. The control group were given inhalation of Budesonide Aerosol, and infants in the observation group were given oral administration of Montelukast Sodium Tablets. Results After treatment, the levels of s erum IL-4 and TNF-a in the observation group were significantly lower than that in the control group, and the level of IFN-γ w a s significantly higher than that of the control group, and the difference was statistically significant （P〈0. 05）. T h e total effective rate and s y m p t o m improvement of the observation group were sig-nificantly better than that of the control group （P〈0. 05）. Conclusion Montelukast is effective in the treatment of asthma in children. Therefore it is worthy of application.
出处
《临床研究》
2018年第1期98-100,共3页
Clinical Research
