摘要
目的探讨年龄相关性黄斑变性(AMD)与血脂的相关性。方法选取AMD患者84例,收集其年龄、性别、疾病史等资料,以体检健康者40名作为正常对照组。分别测定AMD组及正常对照组血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(apo A)、载脂蛋白B(apo B)水平。对AMD组与正常对照组外周血血脂水平进行单因素及多因素Logistic回归分析。结果 AMD组TC、TG、HDL-C、apo A水平明显高于正常对照组(P<0.05)。多因素Logistic回归分析显示TC[比值比(OR)=2.095,95%可信区间(CI)1.277~3.434]、HDL-C(OR=3.106,95%CI1.133~8.513)、apo A(OR=3.588,95%CI 0.768~16.752)为AMD发病的危险因素。结论外周血TC、HDL-C、apo A水平升高可能与AMD的发病存在相关性。
Objective To investigate the correlation between peripheral blood lipid level and age-related macular degeneration（AMD）.Methods A total of 84 AMD patients and 40 healthy subjects were enrolled,and their data of age,sex and disease history were collected. Serum total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A（apo A） and apolipoprotein B（apo B） were determined. The results were analyzed by univariate analysis and multivariate Logistic regression analysis.Results The levels of TC,TG,HDL-C and apo A in AMD group were higher than those in healthy control group（P〈0.05）. Multivariate Logistic regression analysis showed that TC [odds ratio （OR）=2.095,95% confidence interval（CI）1.277-3.434],HDL-C（OR=3.106,95%CI 1.133-8.513） and apo A（OR=3.588,95%CI 0.768-16.752）were risk factors for AMD. Conclusions The increasing levels of peripheral blood TC,HDL-C and apo A may be correlated with the incidence of AMD.
出处
《检验医学》
CAS
2017年第12期1105-1108,共4页
Laboratory Medicine
关键词
血脂
危险因素
年龄相关性黄斑变性
Blood lipid
Risk factor
Age-related macular degeneration
