摘要
促进骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)成骨并抑制其成脂分化是目前骨质疏松症治疗的新靶点。淫羊藿防治骨质疏松症的机制已成为近年来研究热点,研究发现其具有促进BMSCs成骨并抑制其成脂分化等作用。笔者以补肾代表中药淫羊藿促进BMSCs成骨并抑制其成脂分化进展作一综述,为骨质疏松症的干细胞治疗提供新的思路。
Promoting osteogenesis and suppressing adipogenesis of bone marrow mesenchymal stem cells （BMSCs） have been a new target for treatment of osteoporosis. The therapeutic effects and mechanisms of Epimedium in treating osteoporosis have become the focus under study. Experimental studies have shown that epimedium has effects of promoting osteogenesis and suppressing adipogenesis of BMSCs. This paper reviews the role of Epimedium, a representative traditional Chinese kidney-tonifying drug, in promoting osteogen- esis and suppressing adipogenesis of BMSCs, so as to provide new ideas for stem cell treatment of osteoporosis.
作者
李烨
肖亚平
李晶晶
徐晓玉
LI Ye;XIAO Ya-ping;LI Jing-jing;XU Xiao-yu(College of Pharmaceutical Sciences, Institute of Chinese Medi- cine, The Key Subject Constructing Units of Pharmacology of Chinese Materia Medica by the State Administrative Bureau of Traditional Chinese Medicine, Southwest University, Chongqing 400716, China;Department of Pharmacy of the First People＇s Hospital of Yun- nan Province, Kunming 650032, China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2017年第24期2137-2140,共4页
Chinese Pharmaceutical Journal
基金
国家自然科学基金面上项目资助(81473549)
中国博士后科学基金资助项目(2014M562272)
重庆市卫生局中医药科研项目资助(zy201602125)
中央高校基本科研业务费专项资助(XDJK2017D158)
