摘要
目的 :观察氟桂利嗪治疗偏头痛的疗效及其对血浆神经肽Y (NPY)水平的影响。方法 :选择偏头痛病人 6 0例 ,随机分为 2组 ,分别予氟桂利嗪和普萘洛尔治疗 ,观察 2组疗效。并分别测定治疗前后血浆NPY水平 ,做统计学分析。结果 :2组比较 ,氟桂利嗪组与普萘洛尔组偏头痛控制率 (5 4 % ,2 1% )及总有效率 (93% ,71% )的差异有显著意义(均P <0 .0 5 )。治疗后 ,氟桂利嗪组NPY水平降低了 (32± 5 3)ng·L- 1,经t检验 ,差异有显著意义 (P<0 .0 5 ) ,而普萘洛尔组差异无显著意义 (P >0 .0 5 )。结论 :氟桂利嗪治疗偏头痛有效 ,且治疗后血浆神经肽水平降低 。
AIM: To observe the effects of flunarizine on migraine and its influence on the levels of plasma neuropeptide Y(NPY) during the treatment. METHODS: Sixty patients with migraine were randomly divided into two groups. The patients in experiment group were treated with flunarizine. Others were given propranolol. Then the effects of the two groups were compared. At the same time, the plasma levels of NPY were measured before and after treatment respectively, and then these data with statistics were analysed. RESULTS: The control rate and total effective rate of flunarizine group is significantly different from that of the propranolol group(P<0.05). And after the treatment of flunarizine, the plasma levels of NPY were obviously reduced. (P<0.05). While in the propranolol group, there was no obvious difference before and after treatment. CONCLUSION: Flunarizine is an effective drug in treating migraine, and it can probably relieve the spasm of the blood vessels.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2002年第9期521-523,共3页
Chinese Journal of New Drugs and Clinical Remedies
