摘要
目的观察IGT伴或不伴高甘油三酯血症(HTG)患者硫氧还原蛋白相互作用蛋白(TXNIP)与胰岛功能的关系。方法选取IGT患者90例(IGT组),IGT合并HTG患者87例(IGT+HTG组)以及正常对照组(NGT组)90名。检测各组血浆TXNIP水平,静脉葡萄糖耐量试验(IVGTT)评价第一时相胰岛素分泌(FPIR),HOMA-β用于评价基础胰岛功能。结果IGT组血TXNIP水平高于NGT组(P<0.05),而IGT+HTG组TXNIP水平进一步升高,与IGT组比较,差异有统计学意义(P<0.05)。胰岛β细胞功能指数(HOMA-β)和FPIR在NGT组、IGT组、IGT+HTG组逐渐下降,各组间两两比较,差异有统计学意义(P<0.05)。相关分析显示,HOMA-β和FPIR与TXNIP呈负相关(P<0.05)。结论 IGT患者血浆TXNIP升高,合并HTG患者升高更明显;基础胰岛功能及早时相胰岛素分泌功能均与血浆TXNIP相关。
Objective To evaluate the relationship between thioredoxin-interacting protein（TXNIP）and pancreaticβ-cell function in impaired glucose tolerance patients with and without hypertriglyceridemia.Methods A total of 267 subjects were enrolled in this study and divided into three groups：impaired glucose tolerance（IGT）group（n=90）,impaired glucose tolerance and hypertriglyceridemia（IGT＋HTG）group（n=87）and normal glucose tolerance（NGT）group（n=90）.The levels of plasma TXNIP were measured.Intravenous glucose tolerance test was performed to evaluate the first-phase insulin response（FPIR）.HOMA forβ-cell function（HOMA-β）was calculated to evaluate basal pancreaticβ-cell function. Results TXNIP was significantly higher in IGT group than in NGT group（P〈0.05）.TXNIP was much higher in IGT＋HTG group than in IGT group（P〈0.05）.HOMA-βand FPIR were decreased gradually from NGT,IGT to IGT＋HTG（P〈0.05）.Correlation analysis showed that HOMA-βand FPIR were negatively correlated with TXNIP（P〈0.05）. Conclusion The level of TXNIP is increased in IGT,especially in IGT with hypertriglyceridemia.Basal and first-phase isletβ-cell function are all associated with TXNIP.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2017年第12期1086-1089,共4页
Chinese Journal of Diabetes
