摘要
目的 :观察纳洛酮预防中枢性应激性溃疡的疗效。方法 :10 1例中枢神经系统损伤的病人随机分为 3组 :纳洛酮组 37例给予纳洛酮 0 .0 2mg·kg- 1,iv ,q 12h ;奥美拉唑组给予奥美拉唑 4 0mg ,iv ,qd ;硫糖铝组 2 9例给予硫糖铝 1.0 g ,po ,qid ,均连用 2wk。观察应激性溃疡出血的发生率及死亡率。结果 :纳洛酮组的应激性溃疡出血及死亡发生率 (5 % ,3% )显著低于硫糖铝组 (31% ,14% ) ,差异有非常显著或显著意义 (P <0 .0 1或P <0 .0 5 ) ;奥美拉唑组 (6 % ,3% )与硫糖铝组 (31% ,14% )比较 ,差异有显著意义 (P <0 .0 5 ) ;纳洛酮组 (5 % ,3% )与奥美拉唑组 (6 % ,3% )比较 ,差异无显著意义 (P >0 .0 5 )。结论
AIM: To observe the effect of naloxone on preventing central stress ulcer (Cushing's ulcer). METHODS: A total one hundred and one patients with central nervous system (CNS) damage were randomly divided into three groups. Thirty-seven patients in naloxone group were treated with naloxone 0.02 mg·kg -1, iv, q 12 h ×2 wk; thirty-five patients in omeperazole group were treated with omeprazole 40 mg iv, qd ×2 wk, which were given by proton pump to depress gastric acid secretion; twenty-nine patients in sucralfate group were treated with sucralfate 1.0 g, po, qid×2wk. The incident rate of Cushing's ulcer's hemorrhage and the death rate were observed. RESULTS: The rate of Cushing ulcer's hemorrhage and the death rate of the naloxone group were much lower than those of the sucralfate group(5 %,3 % vs 31 %, 14 %, P< 0.01 or P<0.05), the rate of hemorrhage and the death rate of the omeprazole group much lower than those of the sucralfate group (6 %,3 % vs 31 %,14 %, P< 0.05). There was no significant difference of the rate of hemorrhage and death between the naloxone group and the omeprazole group (5 %,3 % vs 6 %, 3 %, P> 0.05). CONCLUSION :Naloxone can effectively decrease the incident rate of central stress ulcer hemorrhage.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2002年第9期544-546,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
纳洛酮
预防
中枢性应激性溃疡出血
stress disorder, post-traumatic
ulcer
hemorrhage
sucralfate
omeprazole
naloxone
