摘要
目的尼莫地平是一种降低蛛网膜下腔出血(SAH)患者发病率和死亡率的疗法,对SAH兔模型,使用功能性CT成像研究尼莫地平的作用。方法在52只新西兰怀孕中诱导SAH兔子随机分为2组:治疗(尼莫地平)或对照组(无治疗)。CT灌注和CT血管造影用于测量SAH后基线水平,10,30和60min的CBF和基底动脉直径,以及第3,5,7,9和16天。结果治疗组基底动脉直径大于对照组SAH后(P<0.05)。当血管痉挛>15%时,尼莫地平组的CBF明显高于对照组脑干,小脑,枕叶脑和深部灰质(P<0.05)。尼莫地平组神经功能评分明显优于对照组,差异有统计学意义(P<0.05)。结论尼莫地平治疗动物显示:1)平均基底动脉直径增加;2)增加平均CBF,尽管延迟性血管痉挛的发生率和严重程度无明显差异。这些数据为未来研究比较了SAH新疗法与尼莫地平疗效的依据。
Objective Nimodipine is a therapy for reducing the incidence and mortality of patients with subarachnoid hemorrhage（ SAH）. The effect of nimodipine was studied by using functional CT imaging by studying the rabbit model of SAH. Methods SAH rabbits were randomly divided into two groups： treatment（ nimodipine） or control group（ no treatment） in 52 new zealand pregnancies. CT perfusion and CT angiography were used to measure basal baseline after SAH,10,30 and 60 minutes of CBF and basilar artery diameter,and days 3,5,7,9 and 16 days. Results The basilar artery diameter of the treatment group was larger than that of the control group（ P〈0. 05）. CBF was significantly higher in the nimodipine group than in the brainstem,cerebellum,occipital lobe and deep gray matter of the control group（ P〈0. 05）. The neurological score of the nimodipine group was significantly better than that of the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Nimodipine treatment of animals showed： 1） increased mean basilar artery diameter; 2） increased mean CBF,although the incidence and severity of delayed vasospasm were not significantly different. These data for the future study compared the efficacy of SAH neoadotherapy with nimodipine.
出处
《医学影像学杂志》
2017年第12期2395-2398,2401,共5页
Journal of Medical Imaging
