摘要
目的:比较^(131)I与甲巯咪唑片分别治疗甲状腺功能亢进症的疗效。方法:选取2015年3月—2016年3月汉川市人民医院收治的甲状腺功能亢进症患者100例作为研究对象,以抽签法分为观察组和对照组,每组50例。对照组患者给予甲巯咪唑片治疗,观察组患者给予^(131)I治疗。观察两组患者的临床疗效及治疗前后的甲状腺功能指标、相关血清指标,比较不良反应发生情况;于1年后观察复发率及远期疗效。结果:观察组患者的总有效率为98.00%(49/50),明显高于对照组的74.00%(37/50),差异有统计学意义(P<0.05);治疗后,观察组患者血清促甲状腺激素、游离甲状腺素及游离三碘甲状腺原氨酸水平明显优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者的碱性磷酸酶、血浆骨钙素、谷胱甘肽过氧化物酶及超氧化物歧化酶水平明显优于对照组,差异均有统计学意义(P<0.05);观察组患者远期总有效率明显高于对照组,差异有统计学意义(P<0.05);随访1年后,观察组患者的复发率为2.00%(1/50),明显低于对照组的20.00%(10/50),差异有统计学意义(P<0.05);观察组患者的并发症发生率为2.00%(1/50),明显低于对照组的32.00%(16/50),差异有统计学意义(P<0.05)。结论:^(131)I治疗甲状腺功能亢进症的疗效显著,可改善患者甲状腺功能,且复发率较低,远期疗效较好。
OBJECTIVE： To probe into the comparison of the efficacy between ^（131）I and thiamazole tablets in treatment of hyperthyroidism. METHODS： 100 patients with hyperthyroidism admitted into Hanchuang People＇s Hospital from Mar. 2015 to Mar. 2016 were selected and divided into observation group and control group via lot method,with 50 cases in each. The control group was treated with thiamazole tablets,while the observation group was given ^（131）I. Clinical efficacy,indices of thyroid function and serum before and after treatment of two groups were observed,difference in incidences of adverse drug reactions between two groups was compared; the relapse rate and long-term efficacy of two groups were observed at 1 year after treatment. RESULTS： The total effective rate of observation group（ 98. 00%,49/50） was significantly higher than that of the control group（ 74. 00%,37/50）,with statistically significant difference（ P〈0. 05）; after treatment,levels of serum thyroid-stimulating hormone（ TSH）,free thyroxine（ FT4） and free triiodothyronine（ FT3） of observation group were significantly better than those of the control group,with statistically significant differences（ P〈0. 05）; after treatment,levels of alkaline phosphatase,plasma osteocalcin,glutathione peroxidase（ GSH-Px） and superoxide dismutase（ SOD） of observation group were significantly better than those of the control group,with statistically significant differences（ P〈0. 05）; the long-term total effective rate of observation group was significantly higher than that of the control group,with statistically significant difference（ P〈0. 05）; after 1 year of follow-up,the relapse rate of observation group（ 2. 00%,1/50） was significantly lower than that of the control group（ 20. 00%,10/50）,with statistically significant difference（ P〈0. 05）; the incidence of complications of observation group（ 2. 00%,1/50） was significantly lower than that of the control group（ 32. 00%,16/50）,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of ^（131）I in treatment of hyperthyroidism is remarkable,which can improve patients thyroid function,with low relapse rate and better long-term efficacy.
出处
《中国医院用药评价与分析》
2017年第11期1491-1493,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
