摘要
目的系统评价中医外治法治疗过敏性紫癜的疗效及安全性。方法计算机检索中国知网、万方数据库、维普数据库及中国生物医学文献数据库,以及Cochrane Library与Pub Med等国外数据库,查找中医外治法治疗过敏性紫癜的随机对照试验,检索时间为各数据库建库至2017年4月9日。2位研究人员分别独立进行文献检索、筛选、质量评价和数据提取,通过Rev Man 5.3软件进行Meta分析。结果共纳入10个随机对照试验研究,总样本量为1340例。Meta分析结果显示,中医外治法治疗过敏性紫癜的治疗组与对照组相比,临床疗效总有效率[RR=1.12,95%CI(1.06,1.18),P<0.0001],治愈率[R R=1.70,95%CI(1.52,1.91),P<0.00001],复发率[R R=0.45,95%CI(0.27,0.76),P=0.002],皮肤紫癜疗效[R R=1.06,95%CI(1.01,1.11),P=0.01],皮疹消失时间[MD=-3.15,95%CI(-3.65,-2.65),P<0.00001],其差异均具有统计学意义(P<0.05)。纳入研究有1项报道了不良反应情况,其余未加以报道。结论中医外治法治疗过敏性紫癜的疗效显著,与常规西药及部分中药治疗相比具有一定优势,但由于本系统评价纳入的研究总体质量较低,研究数量较少,结局指标较单一,故仍需更多大样本、高质量的随机双盲对照试验对中医外治法治疗过敏性紫癜的疗效及安全性加以验证。
Objective To systematically evaluate the efficac y and safety of external therapies of traditional Chinese medicine for allergic purpura. Methods All researches on the randomized controlled trials of allergic purpura treated by external therapies of traditional Chinese medicine were retrieved and collected from Cochrane Library, Pub Med, CNKI, WANFANG, VIP, CBM, each database retrieval time until April 9, 2017. Two researchers respectively retrieved, screened, assessed quality and extracted data.Revman5.3 software was used to analyze. Results Ten studies involving 1340 participants were included. The Meta analysis results showed that the treatment group of external therapies of traditional Chinese medicine on the clinical efficiency was compared with the controlled group [RR=1.12, 95% CI（1.06, 1.18）, P〈0.0001], the cure rate [RR=1.70, 95% CI（1.52, 1.91）, P〈0.00001], the recurrence rate [RR=0.45, 95% CI（0.27, 0.76）, P=0.002], the curative effect of skin purpura [RR=1.06, 95% CI（1.01, 1.11）,P=0.01], the rash disappearance time [MD=-3.15, 95% CI（-3.65,-2.65）, P〈0.00001], and the differences were statistically significant（ P〈0.05）. There was one research that reported untoward effect. Conclusion The external therapies of traditional Chinese medicine for allergic purpura has distinct advantages comparing with conventional Western medicine. But the included researches had low quality, a small quantity and single outcome indicators, so this study still need more large sample and high quality randomized controlled trials to verify.
出处
《中国中医药现代远程教育》
2017年第23期65-68,共4页
Chinese Medicine Modern Distance Education of China
基金
河南中医药大学教育教学改革研究项目【No.2017JX45】
关键词
中医外治法
过敏性紫癜
随机对照试验
META分析
不良反应
文献研究
external therapies of traditional Chinese medicine
allergic purpura
randomized controlled trials
Meta-analysis
adverse reaction
literature research
