摘要
目的探讨促炎及抗炎因子在肝癌合并HBV感染发生发展中的作用。方法选择2015年3月至2016年12月于驻马店市中心医院诊治的33例乙型肝炎、30例肝硬化合并乙型肝炎和46例肝癌合并乙型肝炎作为研究对象,分别称之为肝炎组、肝炎肝硬化组和肝炎肝癌组,其中肝炎组又分为急性组(n=15)和慢性组(n=18);肝炎肝硬化组又分为代偿组(n=18)和失代偿组(n=12);肝炎肝癌组又分为早期组(n=31)和中晚期组(n=15);选取10例健康体检人群作为对照组。采用酶联免疫吸附法检测所有患者血清中促炎因子(IFN-γ、TNF-α以及IL-6)和抗炎因子(IL-4、IL-10以及TGF-β)的水平并进行比较。结果与对照组比较,三组促炎因子及抗炎因子均明显升高(P<0.05),且肝炎组>肝炎硬化组>肝炎肝癌组(P<0.05);在肝炎组中,急性组促炎因子及抗炎因子明显高于慢性组(P<0.05);在肝炎肝硬化组中,失代偿组促炎因子及抗炎因子明显高于代偿组;在肝炎肝癌组,中晚期组促炎因子及抗炎因子明显高于早期组,以上差异均有统计学意义(P<0.05)。结论促炎及抗炎因子在肝癌合并HBV感染不同阶段的诊断及鉴别诊断中具有一定的临床价值。
Objective To explore the effect of pro- inflammatory and anti- inflammatory factors on the occurrence and development of liver cancer with HBV infection. Methods 33 cases of HBV infection, 30 cases of hepatocirrhosis with HBV infection and 46 cases of liver cancer with HBV infection in our hospital from March 2015 to December 2016 were enrolled for our study ; they were referred to as hepatitis group, cirrhosis with hepatitis group and liver cancer with hepatitis group. The hepatitis group was divided into acute group （15 cases） and chronic group （18 cases） ; the cirrhosis with hepatitis group were divided into compensatory group （18 cases） and decompensated group （12 cases） ; the liver cancer with hepatitis group were divided into early stage group （31 cases） and advanced group （15 cases） ; 10 cases of healthy person were regarded as control group. The serum levels of pro-inflammatory cytokines （IFN-β, TNF-α and IL-6） and anti- inflammatory factors （IL-4, IL-10 and TGF-β） were measured by enzyme-linked immunosorbent assay and compared. Results Compared with the control group, the pro-inflammatory factors and anti-inflammatory factors in three groups were significantly increased （P〈0.05）, and hepatitis group 〉 cirrhosis with hepatitis group 〉 liver cancer with hepatitis group （P〈 0.05 ）. In hepatitis group, the levels of pro-inflammatory and anti- inflammatory factors in acute group was significantly higher than those in chronic group （P〈0.05） ; in cirrhosis with hepatitis group, the levels of pro-inflammatory and anti- inflammatory factors in decompensated group was significantly higher than those in compensation group （P〈0.05） ; in liver cancer with hepatitis group, the levels of pro-inflammatory and anti-inflammatory factors in advanced group was significantly higher than those in late group （P〈0.05）. Conclusion Pro-inflammatory and anti-inflammatory factors have some clinical value in the diagnosis and differential diagnosis of liver cancer with HBV infection at different stages.
作者
张金良
王良超
石贵福
ZHANG Jin-liang;WANG Liang-chao;SHI Gui-fu(Zhumadian Central Hospital, Zhumadian, Henan 463000, Chin)
出处
《热带医学杂志》
CAS
2017年第12期1622-1625,共4页
Journal of Tropical Medicine
关键词
肝癌
HBV感染
促炎因子
抗炎因子
Liver cancer
HBV infection
Pro-inflammatory factors
Anti-inflammatory factors
