金水六君煎联合呼吸锻炼治疗稳定期尘肺病肺脾肾虚证临床疗效观察被引量：12

Clinical Efficacy of Jinshui Liujunjian Combined with Breathing Exercises in Treatment of Pneumoconiosis in Stable Phrase with Syndrome of Deficiency of Lung,Spleen and Kidney

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摘要目的：观察金水六君煎结合呼吸锻炼治疗稳定期尘肺病肺脾肾虚证的临床疗效及安全性。方法：选取尘肺稳定期住院患者114例，按照就诊先后，依据分层、随机分为治疗组和对照组，各57例，治疗组患者采用常规西医药物治疗联合金水六君煎及呼吸肌运动疗法，对照组患者采用单纯西医药物治疗，2组疗程均为3个月。分别对治疗前后生活质量评分（SGRQ），营养状态，免疫功能及肺功能，不良反应进行观察，评价治疗效果及安全性。结果：治疗组患者治疗后SGRQ评分较对照组和治疗前均降低（P〈0．05，P〈0．01），治疗组治疗后营养学各项指标（体质指数、上臂肌围长、血清白蛋白、前白蛋白）较对照组和治疗前升高（P〈0．01）。在免疫功能方面，与治疗前比较，治疗组治疗后免疫球蛋白（Ig）G升高，C反应蛋白（CPR），铜蓝蛋白（CP）降低（P〈0．01），与对照组治疗后比较，治疗组IgG水平升高，CP水平下降（P〈0．01）。结论：在常规西医药物治疗基础上，服用金水六君煎结合呼吸锻炼能有效改善稳定期尘肺患者的营养状态，提高其免疫力，并能提高其生活质量，值得进一步推广及应用。 Objective： To observe the clinical efficacy and safety of Jinshui Liujunjian combined with breathing exercises on patients with pneumoconiosis in stable phrase with syndrome of deficiency of lung, spleen and kidney. Method： A total of 114 patients were randomly divided into treatment group and control group, with 57 cases in each group. Patients in treatment group received routine western medicine combined with Jinshui Liujunjian and breathing function exercise, while patients in control group received only pure western medicine. Both groups were treated for 3 months. Life quality score （SGRQ） , nutrition state, immune function and lung function were measured. Result： The SGRQ grade in treatment group after treatment were lower than before treatment in treatment group （P 〈 0. O1 ） and the control group （P 〈 0.05 ）. The nutritional indices （ BMI, MAMC, ALB, PA） in treatment group after treatment were higher than those before treatment in treatment group and control group （P 〈 0. 01 ）. After treatment, the level of IgG in the treatment group were higher than that before treatment （P 〈 0.01 ）, whereas the levels of CPR and CP were lower （P 〈 0.01 ）. Compared with control group, IgG and CP in treatment group were significantly different （P 〈 0.01 ）. Conclusion： Jinshui Liujunjian combined with breathing exercises can improve nutritional state, immunity and quality of life in patients with pneumoconiosis in stable phrase, and thus is worth further promotion and application.

作者邓小峰吴奇峰谭琳曾子芳徐琳陈永君

机构地区广州中医药大学针灸康复临床医学院广东省职业病防治院

出处《中国实验方剂学杂志》 CAS CSCD 北大核心 2018年第2期158-163,共6页 Chinese Journal of Experimental Traditional Medical Formulae

基金广东省中医药局科研项目(20152019) 国家临床重点专科建设项目(2011-09) 广东省职业病防治重点实验室项目(2012A061400007)

关键词金水六君煎呼吸功能锻炼尘肺生活质量营养状态免疫功能肺功能 Jinshui Liujunjian breathing exercise pneumoconiosis quality of life nutritional state immune function pulmonary function