摘要
目的探讨病毒性脑炎及化脓性脑膜炎患儿脑脊液(CSF)1-磷酸鞘氨醇(S1P)的变化。方法选取病毒性脑炎患儿30例,化脓性脑膜炎患儿30例以及非颅内感染患儿(对照组)20例,采用酶联免疫吸附试验定量测定CSF中S1P水平。结果化脑组CSF中S1P水平高于病脑组及对照组[(0.217±0.017)nmol/L vs(0.191±0.010)nmol/L、(0.172±0.015)nmol/L,P<0.05];病脑组CSF中S1P的水平高于对照组[(0.191±0.010)nmol/L vs(0.172±0.015)nmol/L,P<0.05]。结论 S1P参与儿童颅内感染发病过程,在不同病原导致的颅内感染中作用程度可能不同。
Objective To investigate the change of cerebrospinal fluid sphingosine-1-phosphate（S1P）in children with viral encephalitis and purulent meningitis .Methods The diagnosis of 30 cases of purulent meningitis （PM ） ,30 cases of viral meningitis and 20 children without intracranial infection （control group） was enrolled .The level of S1P in CSF was measured using ELISA . Results The level of S1P in CSF in PM group was significantly higher than in the VM and control groups （（0.217 ± 0.017 ） nmol/L vs. （0.191 ± 0.010） nmol/L ,（0.172 ± 0.015） nmol/L ,P〈0.05） .The level of S1P in CSF in VM group was significantly higher than the control group （（0.191 ± 0.010） nmol/L vs .（0.172 ± 0.015） nmol/L ,P〈0.05） .Conclusion S1P involved in the pathogenesis of intracranial infection in children ,in different pathogens caused by the degree of intracranial infection maybe differ-ent .
出处
《中国实用神经疾病杂志》
2017年第24期48-50,共3页
Chinese Journal of Practical Nervous Diseases
基金
河南省教育厅科学技术研究重点项目(13A320662)
关键词
1-磷酸鞘氨醇
脑脊液
病毒性脑炎
化脓性脑膜炎
颅内感染
Sphingosine-1-phosphate
Cerebrospinal fluid
Viral meningitis
Purulent meningitis
Intracranial infection
