摘要
目的探讨雾化吸入异丙托溴铵联合静脉注射盐酸氨溴索预防胸腹切口食管癌术后肺部并发症的疗效。方法选取2014年1月至2017年1月在无锡市第四人民医院心胸外科行胸腹切口食管癌手术的100例患者为观察对象,采用分层随机化分组法分为观察组和对照组各50例。观察组给予雾化吸入异丙托溴铵联合静脉注射盐酸氨溴索,对照组给予雾化吸入α-糜蛋白酶,比较两组患者的咳嗽排痰效果以及术后肺部并发症的差异。结果观察组咳嗽排痰好,47例(94%)不需要床边吸痰,3例需要床边吸痰;对照组咳嗽排痰欠佳,38例(76%)不需要床边吸痰,12例(24%)需要床边吸痰,两组比较差异有统计学意义(P<0.05)。观察组肺部并发症5例,分别是肺炎2例,肺不张2例,急性呼吸窘迫综合征1例;对照组肺部并发症13例,分别是肺炎7例,肺不张4例,急性呼吸窘迫综合征2例。两组比较差异有统计学意义(P<0.05)。结论雾化吸入异丙托溴铵联合静脉注射盐酸氨溴索对预防胸腹切口食管癌术后肺部并发症有较好效果。
Objective Through clinical study,we observed the clinical efficacy of ipratropium bromide inhalation（trade name： atrovent） and ambroxol hydrochloride（trade name： mucosolvin） intravenous injection in prevention of postoperative pulmonary complications in two incisions of thoracic and abdominal esophageal cancer surgery. Methods We selected 100 patients who underwent two incisions of thoracic and abdominal esophageal cancer surgery. They were randomly divided into the treatment group and the control group,50 cases each. The treatment group received ipratropium bromide inhalation and ambroxol hydrochloride intravenous injection,and the control group was given alpha chymotrypsin inhalation. The cough expectoration effect and postoperative pulmonary complications were compared between the two groups. Results The curative effect of cough and expectoration was good in the treatment group. In the treatment group,47 cases（94%） did not need sputum suction at bedside,3 cases needed sputum suction at bedside. In control group,the curative effect of cough and expectoration was poor,38 cases（76%） did not need sputum suction at bedside,and 12 cases（24%） needed sputum suction at bedside. The difference between the two groups was statistically significant（P〈0. 05）. There were 5 cases of pulmonary complications in the treatment group,including 2 cases of pneumonia,2 cases of atelectasis,and 1 case of acute respiratory distress syndrome. There were 13 cases of pulmonary complications in the control group,including 7 cases of pneumonia,4 cases of atelectasis,and 2 cases of acute respiratory distress syndrome. The difference between the two groups was statistically significant（P〈0. 05）. Conclusions Ipratropium bromide inhalation and ambroxol hydrochloride intravenous injection is effective in preventing postoperative pulmonary complications in two incisions of thoracic and abdominal esophageal cancer surgery.
出处
《中国肿瘤外科杂志》
CAS
2017年第6期362-364,共3页
Chinese Journal of Surgical Oncology
关键词
食管肿瘤
鼻雾化吸入法
静脉注射
异丙托溴铵
盐酸氨溴索
肺部并发症
疗效比较研究
Esophageal neoplasms
Method of nasal spray inhalation
Intravenous injection
Ipratropium bromide
Ambroxol hydrochloride
Pulmonary complications
Comparative effectiveness research
