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血清TGF-β1、CEA、CA125水平联合检测对晚期非小细胞肺癌化疗疗效评估价值 被引量:3

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摘要 目的探讨血清癌胚抗原(CEA)、糖类抗原125(CA125)及转化生长因子-β1(TGF-β1)水平联合检测在晚期非小细胞肺癌(NSCLC)化疗疗效评估中的应用价值。方法选取漯河市第二人民医院2014年9月至2016年10月收治的晚期NSCLC患者87例设为研究组,予以GP化疗方案治疗>6 w,化疗前后行肿瘤三维成像及胸部CT检查,依据影像学结果进行分组,其中有效亚组56例、无效亚组31例;另选同期健康体检者41例设为对照组。所有受试者均行血清TGF-β1、CEA、CA125检测,分析比较研究组与对照组血清TGF-β1、CEA、CA125水平,对比研究组各亚组化疗前后血清TGF-β1、CEA、CA125水平。结果研究组血清TGF-β1、CEA、CA125水平高于对照组,差异有统计学意义(P<0.05);研究组两亚组化疗前血清TGF-β1、CEA、CA125水平对比差异无统计学意义(均P>0.05),化疗后两亚组血清TGF-β1、CEA、CA125水平较本组化疗前均有所降低,但有效亚组明显低于无效亚组,差异有统计学意义(P<0.05)。结论晚期NSCLC患者血清TGF-β1、CEA、CA125表达高水平,联合检测有助于NSCLC诊断、临床控制及化疗预后评估。
出处 《中国卫生工程学》 CAS 2017年第6期787-789,共3页 Chinese Journal of Public Health Engineering
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  • 1Ukaszewicz-Zajac M,Mroczko B,Kozlowski M,et al.Elevated levels of serum metalloproteinase 9 in patients with esophageal squamous cell carcinoma[J].Pol Arch Med Wewn,2009,119(9):558-563.
  • 2Mehta J,Prabhu R,Eshpunigani P,et al.Evaluating the efficacy of tumor markers CA19-9 and CEA to predict operability and survival in pancreatic malignancies[J].Trop Gastroenterol,2010,31(3):190-194.
  • 3Jnntermanns B,Radunz S,Heuer M,et al.Tumor markers as a diagnostic key for hilar cholangiocarcinoma[J].Eur J Med Res,2010,15(8):357-361.
  • 4Cedrés Susana,Nu?ez Isaac,Longo Marina,Martinez Pablo,Checa Eva,Torrejón Davis,Felip Enriqueta.Serum tumor markers CEA, CYFRA21-1, and CA-125 are associated with worse prognosis in advanced non-small-cell lung cancer (NSCLC). Clinical Lung Cancer . 2011
  • 5Kang S,Kim TJ,Seo SS,et al.Interaction between preoperative CA-125 level and survival benefit of neoadjuvant chemotherapy in advanced epithelial ovarian cancer.Gynecol Oncol,2011,20(1): 18-22.
  • 6Weinberg LE,Rodriguez G,Hurtean JA.The role of neoadjuvant chemotherapy in treating advanced epithelial ovarian cancer.J Surg Oncol,2010,104(4) :334-343.
  • 7Freedman OC, Dodge J, Shaw P,et al.Diagnosis of epithelial ovarian carcinoma prior to neoadjuvant chemotherapy.Gynecol Oneol, 2010,119( 1 ) : 22-25.
  • 8Vergote l,Trope CG,Amant F,et al.Neoadjuvant chemotherapy or primary surgery in stage 111 C or 1V ovarian Cancer.N Engl J Med, 2010,363 (10) : 943-953,.
  • 9Kyoko Okamura,Koichi Takayama,Miiru Izumi,Taishi Harada,Kazuto Furuyama,Yoichi Nakanishi.Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer[J]. Lung Cancer . 2013
  • 10Liang Yang,Xin Chen,Yue Li.Declines in serum CYFRA21-1 and carcinoembryonic antigen as predictors of chemotherapy response and survival in patients with advanced non-small cell lung cancer. EXPERIMENTAL AND THERAPEUTIC MEDICINE . 2012

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