摘要
目的 探讨磁共振成像（MRI）对儿童后颅窝肿瘤分级诊断的应用价值.方法 回顾性分析2012年1月至2013年12月重庆医科大学附属儿童医院收治的19例经临床和手术病理证实的儿童后颅窝低级别及高级别肿瘤的MRI特征的临床资料,测量肿瘤总体积、实性成分所占比例、周围脑实质水肿率及肿瘤囊变率等,对所获得数据进行统计学分析;按照世界卫生组织（WHO）中枢神经系统肿瘤分类标准分级.结果 病变发生部位：低级别组小脑5例,四脑室4例;高级别组四脑室6例,小脑蚓部4例;合并梗阻性脑积液：低级别组8例（8/9）,高级别组10例（10/10）;肿瘤总体积：低级别组（51.1±3.2）mm3,高级别组（31.9±1.8）mm3,差异有统计学意义（t=2.591,P=0.019）;实性成分所占比例：低级别组41.7%,高级别组66.1%,差异有统计学意义（χ2=6.52,P〈0.05）;合并周围脑实质水肿：低级别组4例（4/9）,高级别组4例（4/10）,差异无统计学意义（χ2=2.591,P=0.274）;肿瘤囊变率：低级别组9例（9/9）,高级别组4例（4/10）,差异无统计学意义（χ2=0.052,P=0.819）.结论 mRI对于儿童后颅窝肿瘤的分级诊断具有重要的应用价值,可为临床制订手术方案提供依据.
Objective To explore the value of magnetic resonance imaging（MRI）in staging diagnosis of posterior fossa tumor in children. Methods The MRI features of low and high grade tumor for posterior fossa brain tumors confirmed by pathology in 19 children treated in Children＆#39;s Hospital of Chongqing Medical University from January 2012 to December 2013 were retrospectively reviewed. The measurement of gross tumor volume, the ratio of solid component, the rate of brain edema and the tumor cystic degeneration rate were studied with statistical analysis, all datum were classified according to the World Health Organization （WHO） central nervous system tumor classification criteria. Results There were 5 cases in cerebellum and 4 cases in four ventricle in the low grade tumor group;there were 6 cases in four ventricle and 4 cases in cauda cerebelli in the high grade tumor group. Combined obstructive hydrocephalus： the low grade tumor group had 8 cases（8/9）, the high grade tumor group had 10 cases （10/10）. The gross tumor volume： （51.2±3.2） mm3for the low grade tumor group, （31.9±1.8） mm3for the high tumor group, there was significantly statistical difference （t= 2.591, P = 0.019）. The ratio of solid components： 41.7 % for the low grade tumor group, 66.1 % for the high tumor group, there was also significantly statistical difference （χ 2= 6.52, P 〈 0.05）. Combined the edema around brain parenchyma： the low grade tumor group had 4 cases（4/9）, the high grade tumor group had 4 cases （4/10）, there was no statistical difference （χ2= 2.591, P = 0.274）. The tumor cystic degeneration： the low grade tumor group had 9 cases （9/9）, the high grade tumor group had 4 cases （4/10）, there was no statistical difference （χ2= 0.052, P = 0.819）. Conclusions MRI has high clinical application values in staging diagnosis of posterior fossa brain tumor in children. It can provide the basis for clinical operation plan.
出处
《肿瘤研究与临床》
CAS
2017年第12期815-818,共4页
Cancer Research and Clinic
关键词
脑肿瘤
颅窝
后
磁共振成像
儿童
肿瘤分级
Brain neoplasms
Cranial fossa,posterior
Magnetic resonance imaging
Child
Tumor grade
