摘要
目的探讨疏肝解郁胶囊对精神分裂症合并长期失眠患者的睡眠指数和精神状态的影响。方法选取2014年4月~2016年5月本院收治精神分裂症合并长期失眠患者100例,按照给药方式不同,将其分为疏肝解郁组和常规组,各50例。常规组患者给予物阿立派唑和阿普唑仑片治疗,疏肝解郁组患者在给予阿立派唑和疏肝解郁胶囊,治疗时间均为6周。对比分析两组患者临床疗效、治疗前后匹斯堡睡眠质量指数(PSQI)评分、治疗前后简明精神病评定量表(BPRS)评分和不良反应发生情况。结果两组患者治疗其按上述量表评分,组间无明显差异(P>0.05);疏肝解郁组患者总有效率高于常规组,差异有统计学意义(P<0.05);两组患者治疗后PSQI每项评分及总分较治疗前均降低,疏肝解郁组患者降低程度明显高于常规组,差异均有统计学意义(P<0.05);疏肝解郁组患者治疗后BPRS每项评分及总分明显低于常规组,差异有统计学意义(P<0.05);疏肝解郁组患者治疗不良反应发生率与常规组无明显差异(P>0.05)。结论疏肝解郁胶囊能有效改善精神分裂症合并长期失眠患者临床疗效,提高睡眠质量,改善精神状态,以及安全性高,值得临床进一步推广应用。
Objective To observe the impact of Shuganjieyu Capsules in the treatment of patients with schizophrenia and chronic insomnia.Methods 100 patients with schizophrenia and chronic insomnia treated in our hospital from April 2014 to May 2016 were retrospectively selected as subjects.All the patients were divided into the experimental group（n=50）and the control group（n=50）.Patients in the experiment group were treated with aripiprazole and Shuganjieyu Capsule for six weeks and in the meantime those in the control group were given aripiprazole and alprazolam.The total clinical effective rate,PSQI scores before and after the treatment,BPRS scores before and after the treatment,and adverse reactions were compared between the two groups.Results There was no significant difference of these scales’ scores mentioned above between the two groups（P〉0.05）;After treatment,the total effective rate of the experimental group was significantly higher than that of the control group（P〈0.05）;the score of each item and the total score of PSQI in the experimental group were significantly lower than that of the control group after treatment（P〈0.05）;the score of each item and the total score of BPRS of the experimental group were significantly lower than that of the control group（P〈0.05）.During the treatment,there was no significant difference between the two groups in terms of adverse reaction（P〉0.05）.Conclusion For patients with schizophrenia and long-term insomnia,Shuganjieyu capsules is clinically more effective and safe to improve the sleep quality and the mental state and is worth further clinical application.
出处
《国际精神病学杂志》
2017年第6期1038-1040,1044,共4页
Journal Of International Psychiatry
