摘要
目的探讨丁苯酞软胶囊治疗帕金森痴呆患者临床疗效,并观察其对患者认知功能及日常生活能力的改善作用。方法截选本院2012年10月~2016年3月收治的共76例帕金森痴呆患者,按照随机数字表法分为对照组与观察组,各38例。两组患者均采用抗抑郁等常规治疗,对照组采用盐酸多奈哌齐片治疗,初始剂量为5mg/d,1次/d;治疗7d后改为10 mg/d,1次/d;观察组采用丁苯酞软胶囊治疗,2粒/次,2次/d。两组均治疗12周,分别于治疗前后采用帕金森病评定量表(UPDRS)评价其病情控制情况,采用蒙特利尔认知评估量表(Mo CA)和简易精神状态量表(MMSE)评价其认知功能缺损及其改善状态,采用日常生活能力(ADL)量表评价其日常生活能力情况。于治疗前后分别检测其血清PAPK7、CRP及NT-3水平。统计分析两组临床疗效及不良反应。结果两组治疗后UPDRS评分均明显低于治疗前,MMSE、ADL及Mo CA评分均明显高于治疗前,观察组治疗后UPDRS评分明显低于对照组,而MMSE、ADL及Mo CA评分明显高于对照组(P<0.05);两组患者治疗后PARK7及CRP水平明显低于治疗前,而NT-3水平明显高于治疗前,观察组治疗后PARK7及CRP水平明显低于对照组,NT-3水平明显高于对照组(P<0.05);观察组治疗后总有效率94.74%,明显高于对照组73.68%(P<0.05),治疗期间无明显不良反应发生。结论应用丁苯酚软胶囊治疗帕金森痴呆可显著改善患者认知功能及日常生活能力,提高临床疗效,且具有较高安全性。
Objective To explore therapeutic effect of butylphthalide soft capsule on Parkinson’s patients with dementia,and observe the effect on improving cognitive function and activity of daily living.Methods Seventy-six patients with Parkinson’s dementia admitted to hospital from October 2012 to March 2016 were selected and divided into the control group and the observation group according to random number table,38 cases in each.Both groups were treated with anti-depressants and other conventional treatment.The control group received hydrochloride donepezil with initial dose of 5 mg/d,1 time/d,which was changed to 10 mg/d,1 time/dafter 7 d.Patients in the observation group were treated with butylphthalide soft capsule,2/time,2 times/d.Both groups were treated for 12 weeks.The Parkinson’s Disease Rating Scale（UPDRS）was used to evaluate the control of the disease before and after 12 weeks of treatment in each group respectively.The Montreal Cognitive Assessment（Mo CA）was used to evaluate cognitive function improvement.The improvement of cognitive impairment was assessed by mini-mental state examination（MMSE）,and the activity of daily living was evaluated via daily living（ADL）scale.Serum PAPK7,CRP and NT-3 levels were also measured before and after treatment.Clinical efficacy and adverse reactions were analyzed.Results After12 weeks UPDRS scores were significantly lower than before,and MMSE,ADL and Mo CA scores were significantly higher than those before treatmentin both groups.UPDRS scoresin the observation group were significantly lower than those in the control group while the MMSE,ADL and Mo CA scores were significantly higher than those in control（P〈0.05）.After 12 weeks PARK7 and CRP levels were significantly lower than those before treatment,and NT-3 levels were significantly higher than those before treatment in both groups.PARK7 and CRP levels in the observation group were significantly lower than those in the control group,and levels of NT-3 were significantly higher than control（P〈0.05）.The total efficiency was94.74% in the observation group,which was significantly higher than 73.68% in control（P〈0.05）.There was no adverse reaction during the treatment period.Conclusion Applicationof butylphenol soft capsules on patients with Parkinson’s dementia can significantly improve the cognitive function and activity of daily living with great clinical efficacy and high security.
出处
《国际精神病学杂志》
2017年第6期1060-1063,共4页
Journal Of International Psychiatry
关键词
帕金森痴呆
丁苯酚软胶囊
盐酸多奈哌齐片
认知功能
日常生活能力
Parkinson’s dementia
Butylphenol soft capsules
Donepezil hydrochloride tablets
Cognitive function
Activity of daily living
