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胸腺肽联合常规疗法对老年COPD继发肺部感染临床疗效的影响 被引量:8

Effect of thymic peptide combined with conventional therapy on clinical efficacy for elderly patients with chronic obstructive pulmonary disease secondary pulmonary infection
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摘要 目的 对老年COPD继发肺部感染患者实施胸腺肽注射液联合常规疗法与单用常规疗法治疗后的临床疗效、生活质量及肺功能进行比较研究.方法 选择2016年3月至2017年3月在我院收治的110例老年COPD继发肺部感染患者,随机分为两组.对照组患者采取常规疗法进行治疗,观察组患者采取胸腺肽注射液联合常规疗法进行治疗.对两组老年COPD继发肺部感染患者治疗后的临床疗效、生活质量、肺功能及免疫功能指标进行比较分析.结果 ①治疗后患者的临床总有效率较对照组明显提高(P〈0.05);②治疗后观察组患者的临床症状评分和生活质量评分均较治疗前和对照组明显降低(P〈0.01);③治疗后观察组患者的FEV1和FVC水平均较治疗前和对照组明显提高(P〈0.05);④治疗后观察组患者的CD3^+、CD4^+/CD8^+和自然杀伤(NK)细胞水平均较治疗前和对照组明显提高(P〈0.05).结论 胸腺肽注射液联合常规疗法可明显提高老年COPD继发肺部感染患者的临床疗效,改善临床症状和生活质量,提高肺功能和免疫功能. Objective To compare thymic peptide injection combined with conventional therapy on clinical efficacy ,quality of life and lung function for elderly patients with chronic obstructive pulmonary disease secondary pulmonary infection .Methods 110 cases of patients with chronic obstructive pulmonary disease secondary pulmonary infection were split into 2 groups .Control group was given conventional therapy alone ,while observation group was given thymic peptide injection combined with conventional therapy .Clinical efficacy ,quality of life ,lung function and immune function of patients in two groups were compared .Results ①Clinical efficacy in observation group after treatment was significantly higher than control group after treatment ( P〈0 .05) .② Scores of clinical symptom and quality of life in observation group after treatment were significantly lower than before treatment and control group after treatment ( P 〈0 .01) .③ Levels of FEV1 and FVC in observation group after treatment were significantly higher than before treatment and control group after treatment ( P 〈 0 .05) .④ Levels of CD3^+ 、CD4^+ /CD8^+ and natural killer ( NK ) cells in observation group after treatment were significantly higher than before treatment and control group after treatment ( P〈0 .05) .Conclusions Thymic peptide injection combined with conventional therapy can effectively enhance clinical efficacy ,improve clinical symptom and quality of life ,and enhance lung function and immune function .
作者 徐瑾
出处 《国际呼吸杂志》 2017年第24期1851-1854,共4页 International Journal of Respiration
关键词 胸腺肽注射液 常规疗法 慢性阻塞性肺疾病 肺部感染 临床疗效 生活质量 肺功能 Thymic peptide injection Conventional therapy Chronic obstructive pulmonary disease Pulmonary infection Clinical efficacy Quality of life Lung function
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