摘要
目的探讨富血小板血浆(PRP)治疗早期膝关节骨关节炎的临床疗效。方法回顾性研究自2016年8月至2017年2月在广州医科大学附属第一医院行自体富血小板血浆注射的膝关节骨关节炎患者19例。所有患者均为早期膝关节骨关节炎,排除晚期膝关节骨关节炎和感染性关节病。每3周注射1次,3次为一疗程。运用疼痛视觉模拟评分(VAS)、国际膝关节文献委员会评分(IKDCS)以及Lysholm膝关节评分(LKS)评价临床疗效。应用SPSS 20.0统计学软件进行分析,用重复测量资料的方差分析比较上述观察指标的变化。结果 19例患者都获得6个月的随访,没有发生注入PRP的明显不良反应,治疗后VAS(F=32.183)、IKDCS(F=66.005)和LKS(F=65.193)与治疗前比较有显著改善,且差异有统计学意义(P<0.01);治疗后1、3、6月间比较,差异有统计学意义(P<0.05)。结论注射PRP治疗早期膝关节骨关节炎可获得满意的临床疗效。
Objective To explore the clinical curative effect of the platelet-rich plasma approach to treat early osteoarthritis of knee .Methods The autologous platelet rich plasma was injected into articular-cavity of 19 patients with knee osteoarthritis from August 2016 and February 2017 in the First Affiliated Hospital of Guangzhou Medical University . All the patients were early knee osteoarthritis ,excluding late knee osteoarthritis and infectious arthropathy .The treatment was administered in series of three intra-knee-articular injections at 3-week interval .The visual analogue scale （ VAS ） ,International Knee Documentation Committee scale （IKDCS）,and the Lysholm knee scale （LKS） were used assessing the effect of treatment .SPSS 20.0 was applied to carry out data processing analysis ,and analysis of variance about repeated measurement data was adopted .Results All the patients were followed up for six months.No severe complication related to the PRP injection was observed .Significant differences were found between pre-and post-injection VAS（F=32.183）,IKDCS（F =66.005）,and LKS（F=65.193） in 19 patients （ all P〈0.01）;the significant differences were also found among the postoperative 6th month,the postoperative 3rd and 1st months in all the patients （ all P 〈0.05 ）.Conclusion The early osteoarthritis of knee can be treated with the PRP injection which could obtain short-term satisfactory clinical effect .
出处
《中华关节外科杂志（电子版）》
CAS
2017年第6期589-592,共4页
Chinese Journal of Joint Surgery(Electronic Edition)
关键词
富血小板血浆
骨关节炎
膝
注射
关节内
Platelet-rich plasma
Osteoarthritis,knee
Injection,intra-articular
