摘要
目的了解手术或放疗后脑膜瘤的复发率范围。方法通过作者2012年12月~2016年12月,27例脑膜瘤手术后随访资料,以及经过文献查询14项已发表的研究进行系统分析,共有2048名患者符合纳入标准。结果 WHOⅠ级脑膜瘤的复发率为0.00~2.36/100人年,WHOⅡ级脑膜瘤为7.35~11.46/100人年。我们的研究结果表明:由于研究人群的异质性,报道复发率是变化的、复杂的,涉及到Simpson分级、纳入放射治疗、放射治疗剂量等;如预期的那样,当控制诊断时间时,WHOⅡ级脑膜瘤一般具有比WHOⅠ级更高的复发率。结论脑膜瘤复发率较难准确预测,各研究报告差异较大可能与治疗的选择和过程有关,需要更严格地的报告脑膜瘤患者的复发率、患者个体WHO分级和Simpson分级的准确性,以保证分析的数据稳定和准确。
Objective To predict recurrence rate by analysis of the literature to determine the recurrence rate ranges of meningiomas following surgery or radiation. Methods This search collected13 studies that met all criteria for inclusion and a total of 2048 patients included in the assessment.Results Recurrence rates of meningiomas ranged from 0.00 to 2.36 per 100-person-years for WHO gradeⅠmeningiomas;and from 7.35 to 11.46 per 100-person-years for WHO grade II meningiomas.From the literature of 14 studies,it was suggested that reported recurrence rates were variable and complicated by the heterogeneity of study populations. WHO gradeⅡmeningiomas generally had a higher recurrence rate than WHO gradeⅠ,when controlling for time of diagnosis. Conclusion Our findings suggest that he recurrence rate of meningioma is difficult to predict accurately.There was a need for more rigorous reporting of recurrence rates,WHO grade,and Simpson grading for individual patients to determine a robust mean of recurrence across WHO grades.
出处
《岭南现代临床外科》
2017年第6期742-746,750,共6页
Lingnan Modern Clinics in Surgery
基金
广东省汕尾市科技计划项目(2010C11)
关键词
脑膜瘤
复发
显微外科
放射
meningioma
recurrence
surgery
radiation
