摘要
目的探讨射频和微波两种消融方案辅助TACE对原发性肝癌患者近期疗效、生存率及肝功能的影响。方法选取收治的原发性肝癌患者共140例,随机分为A组和B组,每组70例。分别在TACE基础上加用微波消融和射频消融治疗;比较2组患者近期疗效,远期生存率,边缘复发率,治疗前后GPT、GOT、TBil、DBil、AFP水平及并发症发生率。结果 2组患者疾病控制率和总有效率比较差异无统计学意义(P>0.05);2组患者边缘复发率比较差异无统计学意义(P>0.05);B组患者治疗后GPT、GOT、TBil及DBil水平均显著低于A组(P<0.05);B组患者治疗后AFP水平显著低于A组、治疗前(P<0.05);同时2组患者并发症发生率比较差异无统计学意义(P>0.05)。结论两种消融方案辅助TACE治疗原发性肝癌具有接近临床疗效和安全性;但射频消融应用可有效减轻肝脏功能损伤程度,价值优于微波消融。
Objective To investigate the effects of two kinds of ablation schemes including radiofrequency ablation and microwave ablation combined with transcatheter hepatic arterial chemoembollzation （TACE） on short-term curative effects, survival rate and liver function of patients with primary hepatic carcinoma. Methods A total of 140 patients with primary hepatic carcinoma who were admitted and treated in our hospital from June 2011 to June 2013 were randomly divided into group A （ n = 70 ） and group B （ n = 70 ）. The patients in group A were treated by microwave ablation combined with TACE, however, the patients in group B were treated by radiofrequency ablation combined with TACE. The short-term curative effects, long term survival rate, relapse rate at lesion＇ s edge, the levels of GPT, GOT, TBil, DBil and AFP before and after treatment as well as incidence rate of complications were observed and compared between two groups. Results There were no significant differences in disease control rate and total effective rate between two groups （ P 〉 0.05 ）, and there were no significant differences in long-term survival rate and relapse rate at lesion＇ s edge between two groups（ P 〉 0.05 ）. However the levels of GPT, GOT, TBil and DBil in group B after treatment were significant lower than those in group A （P 〈0.05）, however the levels of AFP after treatment in observation group were significant lower than those before treatment and those in group A （P 〈 0.05）. Besides there was no significant difference in incidence rate of complications between two groups （ P 〉 0.05）. Conclusion The two kinds of ablation schemes including radiofrequency ablation and microwave ablation combined with TACE in treatment of primary hepatic carcinoma have equal clinical effects and safety, but radiofrequency ablation can effectively relieve the damage degree of liver function, therefor, radiofrequency ablation is superior to microwave ablation.
出处
《河北医药》
CAS
2018年第1期117-119,123,共4页
Hebei Medical Journal
关键词
消融
TACE
原发性肝癌
治疗结果
安全性
ablation
TACE
primary hepatic carcinoma
curative effects
safety
