摘要
目的总结肿瘤相关成纤维细胞(CAFs)对乳腺癌干细胞的影响及其机制的研究现状。方法对近年来有关CAFs与乳腺癌干细胞关系研究的相关文献进行综述。结果 CAFs是乳腺癌间质中最主要的细胞类型,而肿瘤间质又是肿瘤微环境的重要组成部分,肿瘤微环境影响乳腺癌细胞的增殖、黏附、侵袭、转移及复发,乳腺癌组织中有一小群具有自我更新及多向分化潜能的干细胞可能与乳腺癌发生、发展密切相关。乳腺癌干细胞内部表型存在异质性,其可能与乳腺癌的转移过程相关。CAFs可通过上皮间质转化的过程对乳腺癌干细胞的形成起促进作用,同时也影响肿瘤干细胞内部的表型转化,但仍需进一步的研究证据。结论 CAFs在乳腺癌干细胞形成及表型转化过程中扮演重要角色,为探究乳腺癌的治疗途径提供了一种新思路。
Objective To summarize research status and mechanism about effects of carcinoma-associated fibroblasts （CAFs） on breast cancer stem cells. Method Relevant literatures about the relationship between the CAFs and breast cancer stem cells were collected and reviewed. Results CAFs were the majority type of the breast cancer stromal cells. The cancer stromal cell was also the important part of the tumor microenvironment, which could promote the proliferation, adhesion, invasion, and metastasis of the breast cancer. A subpopulation of cancer stem cells with the potentials of self-renewal and multi-directional differentiation in the breast cancer tissues might cause the tumor development. There was a phenotypic heterogeneity in the beast cancer stem cells, it was related to the tumor recurrence and therapy resistance. The CAFs could promote the formation of breast cancer stem cells through the epithelial mesenchymal transition and promote the transformation of tumor stem cell phenotype. More research needed to be done to prove these processes. Conclusion CAFs play an important role in formation of breast cancer stem cells and transformation of tumor stem cell phenotype, which might provide a new idea about treating breast cancer.
出处
《中国普外基础与临床杂志》
CAS
2018年第1期108-112,共5页
Chinese Journal of Bases and Clinics In General Surgery
关键词
乳腺癌
肿瘤干细胞
成纤维细胞
上皮间质转化
肿瘤微环境
breast cancer
cancer stem cell
fibroblast
epithelial mesenchymal transition
tumor micro- environment
