摘要
目的:探讨甲亢患者甲状腺激素水平与骨密度及身体成分的相关性。方法:选取2015年5月至2017年6月在我院就诊的甲亢患者60例,同时选取同期在我院行常规体检的60例志愿者,分别测定游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)水平,同时采用双能X线骨密度仪(DXA)测量身体成分与骨密度。进行统计学分析。结果:甲亢组肌肉量、脂肪量、脂肪百分水平显著低于对照组,差异有统计学意义(P<0.05)。甲亢组局部腰椎、股骨颈、股骨大粗隆BMD水平显著低于对照组,差异有统计学意义(P<0.05)。FT3、FT4、TSH与BMD呈负相关,差异有统计学意义(r值分别为-0.557、-0.421、-0.403P<0.05)。FT3、FT4、TSH与肌肉量、脂肪量、脂肪百分也呈负相关关系,差异有统计学意义(r值分别为-0.538、-0.464、-0.422,P<0.05)。结论:甲亢患者甲状腺激素水平异常会导致身体成分、骨吸收与骨代谢紊乱,出现骨密度下降,呈负相关关系。
Objective： To investigate the correlation between thyroid hormone level and bone mineral density and body composition in patients with hyperthyroidism. Methods： 60 patients with hyperthyroidism who were treated in our hospi- tal from May 2015 to June 2017 were selected. At the same time, 60 volunteers with routine physical examination were select- ed. The free triiodothyronine （F33） Free thyroxine （FT4） and thyrotropin （TSH） levels, and dual body X -ray absorptiome- try （DXA） was used to measure body composition and bone density. Statistical analysis was performed. Results： The percent- age of muscle mass, fat mass and fat percentage in hyperthyroid group was significantly lower than that in control group （ P 〈 0. 05 ）. The BMD level of local lumbar vertebrae, femoral neck and femur was significantly lower than that of the control group （P 〈 0. 05）. FT3, FT4, TSH and BMD were negatively correlated, the difference was statistically significant （r = - 0. 557, - 0. 421, - 0. 403P 〈 0. 05 ）. FT3, FT4, TSH were negatively correlated with muscle mass, fat mass and fat percentage, the difference was statistically significant （ r = - 0. 538, - 0. 464, - 0. 422, P 〈 0.05 ）. Conclusion： The abnormal levels of thyroid hormones in patients with hyperthyroidism could lead to a negative correlation between body composition, bone resorp- tion and bone metabolism, and bone mineral density.
出处
《现代医用影像学》
2017年第5期1161-1163,共3页
Modern Medical Imageology
关键词
甲亢
甲状腺激素
骨密度
Hyperthyroidism
Thyroid hormone
Bone mineral density
