摘要
目的探讨环丝氨酸联合胸腺肽对耐多药肺结核患者痰茵阴转率及血清T细胞亚群、γ-干扰素（IFN-γ）水平变化的影响。方法选取耐多药肺结核患者79例，按照随机数字表法分组，对照组39例予以环丝氨酸治疗，观察组40例予以环丝氨酸＋胸腺肽治疗，观察比较两组痰菌阴转率及血清T细胞亚群（CD4＋、CD8＋、CD4＋／CD8＋）、IFN-γ水平变化情况，并统计两组不良反应发生情况。结果治疗后1年观察组痰菌阴转率为87．50％（35／40），高于对照组的58．97％（23／39），差异有统计学意义（P〈0．05）；治疗后1年观察组CD4＋、CD4＋／CD8＋及血清IFN-γ水平均高于对照组，CD8＋低于对照组，差异有统计学意义（P〈0．05）；观察组不良反应发生率为17．50％（7／40），对照组为10．26％（4／39），差异未见统计学意义（P〉0．05）。结论环丝氨酸与胸腺肽联合治疗可提高耐多药肺结核痰菌阴转率及血清IFN-γ水平，改善血清T细胞亚群，且安全性高。
Objective To investigate the effects of cycloserine combined with thymosin on spu- tum negative conversion rate, serum T cell subsets and interferon-γ （IFN-γ） levels in patients with mul- tidrug resistant tuberculosis. Methods Seventy-nine patients with multidrug resistant tuberculosis were divided into control group （n = 39） and observation group （n = 40） according to random table method; the control group was treated with cycloserine, and the observation group was treated with cycloserine ＋ thymosin; sputum negative rate, serum T cell Subsets （CD4 ＋ , CD8 ＋ , CD4 ＋/CD8 ＋ ） and IFN-7 levels were observed and compared between the two groups, and incidence of adverse effects were recorded. Results The negative rate of sputum in observation group [87. 50% （35/40） ] was higher than that in control group [ （58. 97% （23/39） 1, the difference was statistically significant （P 〈 0. 05 ） ; the levels of CD4＋, CD4 ＋ / CD8 ＋ and serum IFN-γ in observation group were higher than those in control group, and CD8 ＋ was higher than that in control group after 1 year of treatment, and the difference was statistically significant （P 〈 0. 05）; there was no significant difference in the incidence of adverse effects between observation group [17.50% （7/40）1 and control group [10.26% （4/39）3, P〉0.05. Conclusions Cyclosine combined with thymosin in the treatment of muhidrug resistant tuberculosis can improve sputum negative rate, ser- um γ-interferon levels and serum T cell subsets, with high safety.
出处
《中国实用医刊》
2017年第23期93-95,共3页
Chinese Journal of Practical Medicine
关键词
耐多药肺结核
环丝氨酸
胸腺肽
痰茵阴转率
T细胞亚群
Γ-干扰素
Multidrug resistant tuberculosis
Cyeloserine
Thymosin
Sputum negative rate
T cell subsets
γ-interferon
