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阳和通脉片治疗肢体动脉硬化闭塞症疗效分析 被引量:1

Analysis ofthe effect of Yanghe Tongmai Tablets on limb arteriosclerosis obliterans
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摘要 目的观察阳和通脉片对肢体动脉硬化闭塞症血管内皮细胞功能的影响,阐述阳和通脉片临床有效性提供证据。方法肢体动脉硬化闭塞症寒凝证患者240例,随机分为观察组120例,予阳和通脉片口服,每次6片,每日3次;对照组120例,予复方丹参片口服,每次3片,每日3次,2组均以28天为1个疗程。临床观察1个疗程。结果观察组总有效率62.04%,对照组46.23%,2组间差异有统计学意义(P=0.044)。治疗后2组肤温降低、静息痛均较治疗前改善,差异有统计学意义(P<0.05,P<0.01);血清6-酮-前列腺素F_(1α)(6-Keto-PGF_(1α))、血清血栓素B2(TXB2)、一氧化氮(NO)较治疗前升高,内皮素-1(ET-1)降低,差异有统计学意义(P<0.01);观察组治疗后皮肤发凉、间歇性跛行及踝肱指数(ABI)改善,与治疗前比较差异亦有统计学意义(P<0.01,P<0.05)。治疗后,2组间皮肤发凉、肤温降低、间歇性跛行、静息痛、ABI、6-Keto-PGF_(1α)、TXB2、NO、ET-1水平比较,差异有统计学意义(P<0.05,P<0.01)。结论阳和通脉片治疗肢体动脉硬化闭塞症寒凝证能改善临床缺血症状和体征,同时具有舒张血管,抑制血栓形成,改善微循环,保护内皮细胞的作用。 Objective To observe the effect of Yanghe Tongmai Tablets on the function of vascular endothelial cells in extremity arteriosclerosis obliterans, and provide the evidence of clinical effectiveness of the tablets. Methods 240 cases of patients with limb arteriosclerosis obliterans of cold accumulation syndrome were randomly divided into an observation group of 120 cases treated with Yanghe Tongmai Tablets, 6 tablets each time, 3 times a day orally, and a control group of 120 cases, with Compound Salvia Tablets, 3 tablets each time, 3 times a day orally, 28 days for 1 course. 1 courses of treatment were observed clinically. Results The total effective rate of the observation group was 62. 04%, and that of the control group was 46. 23%, and the difference between the two groups was statistically significant(P = 0. 044). After the treatment, skin temperature reduction and resting pain were improved in both two groups compared with that before the treatment, the differences were statistically significant( P 〈 0. 05, P 〈 0. 01 ) ; serum 6- keto prostaglandin Fla, thromboxane B2(TXB2), and nitric oxide(NO) were increased compared with those before the treatment, endothelin-1 (ET-1) was decreased, the difference was statistically significant (P 〈 0. 01 ); in the observation group, cold skin, intermittent claudication and ankle brachial index (ABI) were improved, compared with those before the treatment, the differences were also statistically significant (P 〈 0. 01, P 〈0. 05). After the treatment, there was a statistically significant difference in cold skin, skin temperature lowering, intermittent claudication, resting pain, ABI, 6-Keto-PGF 1α, TXB2, NO and ET-1 between the two groups ( P 〈 0. 05, P 〈 0. 01 ). Conclusion Yanghe Tongmai Tablets in the treatment of arteriosclerosis obliterans of cold accumulation syndrome has significant curative effect, and it can improve the clinical symptoms and signs of ischemia, dilate blood vessels, inhibit thrombosis, improve microcirculation, and protect endothelial cells.
出处 《北京中医药》 2017年第11期973-976,共4页 Beijing Journal of Traditional Chinese Medicine
基金 上海市科学技术委员会科研计划项目(14401972800)
关键词 肢体动脉硬化闭塞症 寒凝证 阳和通脉片 血管内皮细胞功能 踝肱指数 arteriosclerosis obliterans cold accumulation syndrome Yanghe Tongmai Tablets vascular endothelial function ankle brachial index
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