摘要
以蒙脱土负载I_2为催化剂,芳香醛、苯乙酮、苯胺为原料进行Mannich反应.单因素法筛选最优催化剂、溶剂、反应时间、温度及原料摩尔比.获得的最优条件为:反应时间5 h,温度25℃,原料芳香醛(1)-苯乙酮(2)-芳香胺(3)摩尔比为1.0∶1.0∶0.9,产率在85.1%~98.8%之间,产物通过红外、核磁、熔点进行表征.
Mannich reaction catalyzed by ioaded Iodine use aromatic aldehyde, acetophenone, aniline as starting materials.The effects of catalyst, solvent, reaction time, temperature and quivalency of starting materials on yield were investigated by single factor method.The optimal conditions are：reaction temperature is 25 ℃, the reaction time is 5 h, the molar ratio of raw materials was 1 ： 1 ： 0.9.The yields range from 85.1% to 98.8% and the product is characterized by IR, NMR and melting point.
出处
《云南大学学报（自然科学版）》
CAS
CSCD
北大核心
2018年第1期132-138,共7页
Journal of Yunnan University(Natural Sciences Edition)
基金
贵州师范大学研究生创新基金(研创201620)
国家自然科学基金(21362006)
贵州省科技创新人才团队建设项目(黔科合人才团队[2014]4006号)
关键词
曼尼希反应
负载催化
蒙脱土
碘
Mannich reaction
load catalysis
montmorillonite
iodine
