摘要
目的观察曲美他嗪对慢性心力衰竭(CHF)患者的临床疗效,探讨其治疗CHF的机制。方法选取我院2016年2月~2017年2月收治的100例CHF患者作为研究对象,随机分为治疗组和对照组,每组各50例。对照组患者接受基础治疗(ACEI、洋地黄、利尿剂、β受体阻滞剂),治疗组加用曲美他嗪。随访3个月后观察治疗的有效率、左室射血分数(LVEF)、左室收缩末期容积(LVDS)、左室舒张末期容积(LVDD)、血浆脑钠肽(NT-proBNP)的变化。结果治疗组患者的临床总有效率均高于对照组,差异有统计学意义(P<0.05),治疗组患者的左室舒张及收缩末期末径缩小,左室射血分数上升,NT-proBNP水平下降,改善情况优于对照组,差异有统计学意义(P<0.05)。结论在以传统心衰治疗的基础上使用曲美他嗪治疗慢性心力衰竭能显著改善患者的左心重构及左心功能。
Objective To evaluate the effects of Trimetazadine on patients with chronic heart failure.Methods 100 patients with chronic heart failure treated in our hospital form February 2016 to February 2017 were selected as the subjects,and divided into therapy group and control group,50 cases in each group.The control group patients were given basic treatment with angiotensin converting enzyme inhibitor （ACEI）,digitalis,diuretics,13block.And the therapy group were given Trimetazadine in addition to the basic treatment Heart function,LVEF, LVDD,LVDS and BNP level in those patients were 0bserv,ed before and after three months treatment.Results Compared with the control group,the total effective rate increased significantly in the therapy group.After treatment,the LVEF of the patients was obviously improved,and RHR in therapy group was decreased.LVDD,LVDS and BNP level also decreased at 3 months compared with those in therapy group,the difference was statistically significant （P〈0.05）.Conclusion In additional to the conventional therapy, Trimetazadine can improve the left ventricular performance and remodeling in patients with coronary heart failure.
出处
《中国当代医药》
2018年第2期123-125,共3页
China Modern Medicine
基金
广东省梅州市科技计划项目(2016B045)
关键词
曲美他嗪
慢性心力衰竭
效果
Trimetazadine
Coronary heart disease（CHF）
Effecacy
