摘要
酒精性肝炎(AH)是酒精性肝病(ALD)类型之一,发病比例较高。其中的重症酒精性肝炎(SAH)属AH的特殊表达类型,其病情险恶,病死率高,现有疗效不佳。现国际上对其尚未有明确诊断标准,除戒酒与营养支持是明确治疗手段外,在众多药物中,常用糖皮质激素(CS)和己酮可可碱(PTX)等来治疗AH,另外一些新型靶点药物的上市对于AH疗效提供了更广阔的研究方向。目前由于AH发病机制尚不完全清楚,因此缺少较为有效治疗的方法,上述药物疗效存在很大争议,这还需要更进一步深入研究和发展。
Alcoholic hepatitis(AH) is one type alcoholic liver diseases with high onset proportion.Severe alcoholic hepatitis(SAH) is one special type of AH,with severe syndrome and high fatality rate.Internationally,there are no definite diagnostic criteria and its treatment effect was not sastisfactory.Besides treatment methods like alcoholic temperance and nutritional support,glucocorticoid(CS) and hexanone theobromine(PTX) were normally used for the treatment of AH among medicines.The introduction of new target drugs provides broad reseach prospectives for improving the treatment effect of AH. At present,because of unidentified mechanism of AH and lack of effective treatment methods,the effects of those medicines were still controversial and need to be further studied and developed.
出处
《中国疗养医学》
2018年第2期133-136,共4页
Chinese Journal of Convalescent Medicine
关键词
酒精性肝病
酒精性肝炎
诊疗机制
进展
Alcoholic liver disease
Alcoholic hepatitis
Diagnosis and treatment mechanism
Progress
